1buo

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[[Image:1buo.png|left|200px]]
 
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{{STRUCTURE_1buo| PDB=1buo | SCENE= }}
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==BTB DOMAIN FROM PLZF==
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<StructureSection load='1buo' size='340' side='right'caption='[[1buo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===BTB DOMAIN FROM PLZF===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1buo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BUO FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9770450}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1buo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1buo OCA], [https://pdbe.org/1buo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1buo RCSB], [https://www.ebi.ac.uk/pdbsum/1buo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1buo ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1buo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUO OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/ZBT16_HUMAN ZBT16_HUMAN] Defects in ZBTB16 are the cause of skeletal defects genital hypoplasia and mental retardation (SGYMR) [MIM:[https://omim.org/entry/612447 612447]. A disorder characterized by mental retardation, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia.<ref>PMID:18611983</ref> Note=A chromosomal aberration involving ZBTB16 may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with RARA.
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==Reference==
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== Function ==
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<ref group="xtra">PMID:009770450</ref><references group="xtra"/>
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[https://www.uniprot.org/uniprot/ZBT16_HUMAN ZBT16_HUMAN] Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.<ref>PMID:14528312</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bu/1buo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1buo ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ahmad, K F.]]
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[[Category: Large Structures]]
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[[Category: Engel, C K.]]
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[[Category: Ahmad KF]]
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[[Category: Prive, G G.]]
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[[Category: Engel CK]]
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[[Category: Gene regulation]]
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[[Category: Prive GG]]
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[[Category: Promyelocytic leukemia]]
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[[Category: Protein structure]]
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[[Category: Protein-protein interaction domain]]
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[[Category: Transcriptional repressor]]
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[[Category: Zinc-finger protein]]
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Current revision

BTB DOMAIN FROM PLZF

PDB ID 1buo

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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