1co4

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[[Image:1co4.png|left|200px]]
 
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{{STRUCTURE_1co4| PDB=1co4 | SCENE= }}
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==SOLUTION STRUCTURE OF A ZINC DOMAIN CONSERVED IN YEAST COPPER-REGULATED TRANSCRIPTION FACTORS==
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<StructureSection load='1co4' size='340' side='right'caption='[[1co4]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1co4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata_CBS_138 Candida glabrata CBS 138]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CO4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1co4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co4 OCA], [https://pdbe.org/1co4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1co4 RCSB], [https://www.ebi.ac.uk/pdbsum/1co4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1co4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMT1_CANGA AMT1_CANGA] Trans-acting regulatory protein that activates transcription of the MT genes (metallothionein) in response to copper or silver ions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1co4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1co4 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three dimensional structure of the N-terminal domain (residues 1-42) of the copper-responsive transcription factor Amtl from Candida glabrata has been determined by two-dimensional 1H-correlated nuclear magnetic resonance (NMR) methods. The domain contains an array of zinc-binding residues (Cys-X2-Cys-X8-Cys-X-His) that is conserved among a family of Cu-responsive transcription factors. The structure is unlike those of previously characterized zinc finger motifs, and consists of a three-stranded antiparallel beta-sheet with two short helical segments that project from one end of the beta-sheet. Conserved residues at positions 16, 18 and 19 form a basic patch that may be important for DNA binding.
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===SOLUTION STRUCTURE OF A ZINC DOMAIN CONSERVED IN YEAST COPPER-REGULATED TRANSCRIPTION FACTORS===
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Solution structure of a zinc domain conserved in yeast copper-regulated transcription factors.,Turner RB, Smith DL, Zawrotny ME, Summers MF, Posewitz MC, Winge DR Nat Struct Biol. 1998 Jul;5(7):551-5. PMID:9665167<ref>PMID:9665167</ref>
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{{ABSTRACT_PUBMED_9665167}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1co4" style="background-color:#fffaf0;"></div>
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[[1co4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO4 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:009665167</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Posewitz, M C.]]
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[[Category: Large Structures]]
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[[Category: Smith, D L.]]
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[[Category: Posewitz MC]]
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[[Category: Summers, M F.]]
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[[Category: Smith DL]]
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[[Category: Turner, R B.]]
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[[Category: Summers MF]]
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[[Category: Winge, D R.]]
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[[Category: Turner RB]]
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[[Category: Zawrotny, M E.]]
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[[Category: Winge DR]]
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[[Category: Amt]]
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[[Category: Zawrotny ME]]
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[[Category: Metal regulation]]
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[[Category: Metallothionein]]
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[[Category: Translation-regulation protein complex]]
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Current revision

SOLUTION STRUCTURE OF A ZINC DOMAIN CONSERVED IN YEAST COPPER-REGULATED TRANSCRIPTION FACTORS

PDB ID 1co4

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