4erm

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[[Image:4erm.png|left|200px]]
 
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{{STRUCTURE_4erm| PDB=4erm | SCENE= }}
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==Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex at 4 Angstroms resolution==
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<StructureSection load='4erm' size='340' side='right'caption='[[4erm]], [[Resolution|resolution]] 3.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4erm]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ERM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ERM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAT:2-DEOXYADENOSINE-5-DIPHOSPHATE'>DAT</scene>, <scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4erm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4erm OCA], [https://pdbe.org/4erm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4erm RCSB], [https://www.ebi.ac.uk/pdbsum/4erm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4erm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines.
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===Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex at 4 Angstroms resolution===
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==See Also==
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*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
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{{ABSTRACT_PUBMED_22727814}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli K-12]]
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[[4erm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ERM OCA].
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[[Category: Large Structures]]
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[[Category: Escherichia coli k-12]]
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[[Category: Drennan CL]]
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[[Category: Ribonucleoside-diphosphate reductase]]
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[[Category: Zimanyi CM]]
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[[Category: Drennan, C L.]]
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[[Category: Zimanyi, C M.]]
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[[Category: Alpha/beta barrel]]
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[[Category: Atp cone]]
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[[Category: Cytosol]]
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[[Category: Di-iron center]]
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[[Category: Oxidoreductase]]
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[[Category: Protein-protein complex]]
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[[Category: Ribonucleotide reduction]]
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[[Category: Rnr alpha]]
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[[Category: Rnr beta]]
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[[Category: Thioredoxin]]
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Current revision

Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex at 4 Angstroms resolution

PDB ID 4erm

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