4hf1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of IscR bound to its promoter== | |
| - | + | <StructureSection load='4hf1' size='340' side='right'caption='[[4hf1]], [[Resolution|resolution]] 2.22Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4hf1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HF1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.222Å</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hf1 OCA], [https://pdbe.org/4hf1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hf1 RCSB], [https://www.ebi.ac.uk/pdbsum/4hf1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hf1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ISCR_ECOLI ISCR_ECOLI] Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. Transcriptional repressor of the iscRSUA operon, which is involved in the assembly of Fe-S clusters into Fe-S proteins. In its apoform, under conditions of oxidative stress or iron deprivation, it activates the suf operon, which is a second operon involved in the assembly of Fe-S clusters. Represses its own transcription as well as that of toxin rnlA.<ref>PMID:11742080</ref> <ref>PMID:16824106</ref> <ref>PMID:20421606</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Phillips KJ]] | ||
| + | [[Category: Rajagopalan SR]] | ||
Current revision
Crystal Structure of IscR bound to its promoter
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