1p7b

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[[Image:1p7b.gif|left|200px]]<br /><applet load="1p7b" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1p7b, resolution 3.65&Aring;" />
 
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'''Crystal structure of an inward rectifier potassium channel'''<br />
 
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==Overview==
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==Crystal structure of an inward rectifier potassium channel==
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The KirBac1.1 channel belongs to the inward-rectifier family of potassium channels. Here we report the structure of the entire prokaryotic Kir channel assembly, in the closed state, refined to a resolution of 3.65 angstroms. We identify the main activation gate and structural elements involved in gating. On the basis of structural evidence presented here, we suggest that gating involves coupling between the intracellular and membrane domains. This further suggests that initiation of gating by membrane or intracellular signals represents different entry points to a common mechanistic pathway.
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<StructureSection load='1p7b' size='340' side='right'caption='[[1p7b]], [[Resolution|resolution]] 3.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1p7b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P7B FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7b OCA], [https://pdbe.org/1p7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p7b RCSB], [https://www.ebi.ac.uk/pdbsum/1p7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P83698_BURPE P83698_BURPE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/1p7b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p7b ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1P7B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei] with <scene name='pdbligand=K:'>K</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7B OCA].
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of the potassium channel KirBac1.1 in the closed state., Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA, Science. 2003 Jun 20;300(5627):1922-6. Epub 2003 May 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12738871 12738871]
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[[Category: Burkholderia pseudomallei]]
[[Category: Burkholderia pseudomallei]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Antcliff, J F.]]
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[[Category: Antcliff JF]]
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[[Category: Ashcroft, F M.]]
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[[Category: Ashcroft FM]]
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[[Category: Cuthbertson, J.]]
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[[Category: Cuthbertson J]]
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[[Category: Doyle, D A.]]
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[[Category: Doyle DA]]
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[[Category: Ezaki, T.]]
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[[Category: Ezaki T]]
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[[Category: Gulbis, J M.]]
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[[Category: Gulbis JM]]
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[[Category: Kuo, A.]]
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[[Category: Kuo A]]
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[[Category: Lowe, E D.]]
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[[Category: Lowe ED]]
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[[Category: Rahman, T.]]
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[[Category: Rahman T]]
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[[Category: Zimmer, J.]]
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[[Category: Zimmer J]]
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[[Category: K]]
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[[Category: cytosolic assembly]]
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[[Category: immunoglobulin fold]]
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[[Category: ion conduction]]
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[[Category: transmembrane helices]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:25:53 2008''
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Current revision

Crystal structure of an inward rectifier potassium channel

PDB ID 1p7b

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