2lkq
From Proteopedia
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- | [[Image:2lkq.jpg|left|200px]] | ||
- | + | ==NMR structure of the lambda 5 22-45 peptide== | |
+ | <StructureSection load='2lkq' size='340' side='right'caption='[[2lkq]]' scene=''> | ||
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[2lkq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKQ FirstGlance]. <br> | ||
+ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkq OCA], [https://pdbe.org/2lkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lkq RCSB], [https://www.ebi.ac.uk/pdbsum/2lkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkq ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Disease == | ||
+ | [https://www.uniprot.org/uniprot/IGLL1_HUMAN IGLL1_HUMAN] Defects in IGLL1 are the cause of agammaglobulinemia type 2 (AGM2) [MIM:[https://omim.org/entry/613500 613500]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/IGLL1_HUMAN IGLL1_HUMAN] Critical for B-cell development.<ref>PMID:9419212</ref> | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | During B cell differentiation in the bone marrow, the expression and activation of the pre-B cell receptor (pre-BCR) constitutes a crucial checkpoint for B cell development. Both constitutive and ligand-dependent pre-BCR activation modes have been described. The pre-BCR is constituted of an immunoglobulin heavy chain (Igmu) and of a surrogate light chain (SLC) composed of the invariant lambda5 and VpreB proteins. We previously showed that Galectin-1 (GAL1), produced by bone marrow stromal cells, is a pre-BCR ligand that induces receptor clustering, leading to efficient pre-BII cell proliferation and differentiation. GAL1 interacts with the pre-BCR via the unique region of lambda5 (lambda5-UR). Here we investigated the solution structure of a minimal lambda5-UR motif that interacts with GAL1. This motif adopts a stable helical conformation that docks onto a GAL1 hydrophobic surface adjacent to its carbohydrate-binding site (CBS). We identified key hydrophobic residues from the lambda5-UR as crucial for the interaction with GAL1 and for pre-BCR clustering. These residues involved in GAL1-induced pre-BCR activation are different to those essential for autonomous receptor activation. Overall, our results indicate that constitutive and ligand-induced pre-BCR activation could occur in a complementary manner. | ||
- | + | Structural basis for galectin-1-dependent pre-B cell receptor (pre-BCR) activation.,Elantak L, Espeli M, Boned A, Bornet O, Bonzi J, Gauthier L, Feracci M, Roche P, Guerlesquin F, Schiff C J Biol Chem. 2012 Nov 2. PMID:23124203<ref>PMID:23124203</ref> | |
- | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
- | == | + | </div> |
- | [[ | + | <div class="pdbe-citations 2lkq" style="background-color:#fffaf0;"></div> |
- | [[Category: Boned | + | == References == |
- | [[Category: Bornet | + | <references/> |
- | [[Category: Breton | + | __TOC__ |
- | [[Category: Elantak | + | </StructureSection> |
- | [[Category: Espeli | + | [[Category: Homo sapiens]] |
- | [[Category: Feracci | + | [[Category: Large Structures]] |
- | [[Category: Guerlesquin | + | [[Category: Boned A]] |
- | [[Category: Roche | + | [[Category: Bornet O]] |
- | [[Category: Schiff | + | [[Category: Breton C]] |
- | + | [[Category: Elantak L]] | |
- | + | [[Category: Espeli M]] | |
- | + | [[Category: Feracci M]] | |
+ | [[Category: Guerlesquin F]] | ||
+ | [[Category: Roche P]] | ||
+ | [[Category: Schiff C]] |
Current revision
NMR structure of the lambda 5 22-45 peptide
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Categories: Homo sapiens | Large Structures | Boned A | Bornet O | Breton C | Elantak L | Espeli M | Feracci M | Guerlesquin F | Roche P | Schiff C