1p9h

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[[Image:1p9h.gif|left|200px]]<br /><applet load="1p9h" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1p9h, resolution 1.55&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE COLLAGEN-BINDING DOMAIN OF YERSINIA ADHESIN YadA'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF THE COLLAGEN-BINDING DOMAIN OF YERSINIA ADHESIN YadA==
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The crystal structure of the recombinant collagen-binding domain of Yersinia adhesin YadA from Yersinia enterocolitica serotype O:3 was solved at 1.55 A resolution. The trimeric structure is composed of head and neck regions, and the collagen binding head region is a novel nine-coiled left-handed parallel beta-roll. Before the beta-roll, the polypeptide loops from one monomer to the rest, and after the beta-roll the neck region does the same, making the transition from the globular head region to the narrower stalk domain. This creates an intrinsically stable 'lock nut' structure. The trimeric form of YadA is required for collagen binding, and mutagenesis of its surface residues allowed identification of a putative collagen-binding surface. Furthermore, a new structure-sequence motif for YadA beta-roll was used to identify putative YadA-head-like domains in a variety of human and plant pathogens. Such domains may therefore be a common bacterial strategy for avoiding host response.
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<StructureSection load='1p9h' size='340' side='right'caption='[[1p9h]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1p9h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_enterocolitica Yersinia enterocolitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9h OCA], [https://pdbe.org/1p9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9h RCSB], [https://www.ebi.ac.uk/pdbsum/1p9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/YADA1_YEREN YADA1_YEREN] Collagen-binding outer membrane protein forming a fibrillar matrix on the bacterial cell surface. Promotes initial attachment and invasion of eukaryotic cells. Also protects the bacteria by being responsible for agglutination, serum resistance, complement inactivation and phagocytosis resistance.<ref>PMID:2592347</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/1p9h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p9h ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1P9H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_enterocolitica Yersinia enterocolitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9H OCA].
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*[[Adhesin 3D structures|Adhesin 3D structures]]
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== References ==
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==Reference==
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<references/>
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The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel beta-roll., Nummelin H, Merckel MC, Leo JC, Lankinen H, Skurnik M, Goldman A, EMBO J. 2004 Feb 25;23(4):701-11. Epub 2004 Feb 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14765110 14765110]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Yersinia enterocolitica]]
[[Category: Yersinia enterocolitica]]
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[[Category: Goldman, A.]]
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[[Category: Goldman A]]
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[[Category: Merckel, M C.]]
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[[Category: Merckel MC]]
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[[Category: Nummelin, H.]]
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[[Category: Nummelin H]]
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[[Category: Skurnik, M.]]
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[[Category: Skurnik M]]
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[[Category: collagen-binding]]
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[[Category: left-handed beta-roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:26:34 2008''
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Current revision

CRYSTAL STRUCTURE OF THE COLLAGEN-BINDING DOMAIN OF YERSINIA ADHESIN YadA

PDB ID 1p9h

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