3o15

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[[Image:3o15.png|left|200px]]
 
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{{STRUCTURE_3o15| PDB=3o15 | SCENE= }}
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==Crystal Structure of Bacillus subtilis Thiamin Phosphate Synthase Complexed with a Carboxylated Thiazole Phosphate==
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<StructureSection load='3o15' size='340' side='right'caption='[[3o15]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3o15]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O15 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3NM:4-METHYL-5-[2-(PHOSPHONOOXY)ETHYL]-1,3-THIAZOLE-2-CARBOXYLIC+ACID'>3NM</scene>, <scene name='pdbligand=IFP:2-TRIFLUOROMETHYL-5-METHYLENE-5H-PYRIMIDIN-4-YLIDENEAMINE'>IFP</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o15 OCA], [https://pdbe.org/3o15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o15 RCSB], [https://www.ebi.ac.uk/pdbsum/3o15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o15 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THIE_BACSU THIE_BACSU] Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Is also able to use the 2-methoxy analog MeO-HMP-PP, as substrate in vitro, but not the 2-trifluoromethyl analog CF(3)-HMP-PP.<ref>PMID:9139923</ref> <ref>PMID:11513588</ref>
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===Crystal Structure of Bacillus subtilis Thiamin Phosphate Synthase Complexed with a Carboxylated Thiazole Phosphate===
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==See Also==
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*[[Thiamin phosphate synthase|Thiamin phosphate synthase]]
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== References ==
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==About this Structure==
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<references/>
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[[3o15]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O15 OCA].
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Thiamine-phosphate diphosphorylase]]
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[[Category: Large Structures]]
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[[Category: Abdelwahed, S.]]
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[[Category: Abdelwahed S]]
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[[Category: Begley, T P.]]
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[[Category: Begley TP]]
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[[Category: Ealick, S E.]]
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[[Category: Ealick SE]]
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[[Category: Hanes, J W.]]
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[[Category: Hanes JW]]
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[[Category: Hazra, A.]]
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[[Category: Hazra A]]
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[[Category: Ishida, K.]]
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[[Category: Ishida K]]
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[[Category: Mahanta, N.]]
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[[Category: Mahanta N]]
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[[Category: McCulloch, K M.]]
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[[Category: McCulloch KM]]
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[[Category: Protein-intermediate complex]]
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[[Category: Thiamin biosynthesis]]
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[[Category: Tim barrel]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Bacillus subtilis Thiamin Phosphate Synthase Complexed with a Carboxylated Thiazole Phosphate

PDB ID 3o15

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