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Factor inhibiting HIF

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{{STRUCTURE_1mzf| PDB=1mzf | SIZE=400| SCENE= |right|CAPTION=Monomer of the dimeric factor inhibiting HIF complex with oxogluterate derivative, [[1mzf]] }}
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<StructureSection load='1mzf' size='350' side='right' scene='48/480806/Cv/1' caption='Dimeric factor inhibiting HIF complex with oxogluterate derivative (PDB code [[1mzf]]) '>
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For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen.
 
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{{TOC limit|limit=2}}
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For details on '''Factor inhibiting HIF''' or '''Hypoxia-inducible factor 1-alpha inhibitor''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/5'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>.
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<scene name='48/480806/Cv/6'>Fe/2-oxogluterate binding site</scene> (PDB code [[1mzf]]).<ref>PMID:12432100</ref>
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</StructureSection>
== 3D Structures of factor inhibiting HIF ==
== 3D Structures of factor inhibiting HIF ==
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''Update June 2012''
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1mze]], [[1h2n]], [[1iz3]] – hFIH1α – human
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*FIH1α
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===FIH1α complex with small molecule===
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**[[1mze]], [[1h2n]], [[1iz3]] – hFIH1α – human
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[[1yci]], [[3od4]], [[2yc0]], [[2yde]]– hFIH1α + inhibitor<br />
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*FIH1α complex with small molecule
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[[2w0x]] - hFIH1α + pyridine derivative<br />
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[[2cgn]] – hFIH1α + succinate<br />
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[[2cgo]] – hFIH1α + fumarate<br />
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[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]] – hFIH1α + oxoglutarate derivative<br />
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[[3kcx]], [[3kcy]], [[3od4]] - hFIH1α + quinol derivative<br />
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===FIH1α complex with polypeptide===
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**[[1yci]], [[3od4]], [[2yc0]], [[2yde]] – hFIH1α + inhibitor<br />
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**[[2w0x]] - hFIH1α + pyridine derivative<br />
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**[[2cgn]] – hFIH1α + succinate<br />
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**[[2cgo]] – hFIH1α + fumarate<br />
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**[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]], [[4z2w]], [[5jwk]], [[7a1j]], [[7a1k]], [[7a1l]], [[7a1m]] – hFIH1α + oxoglutarate derivative<br />
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**[[5jwk]], [[5jwl]] - hFIH1α (mutant) + ketoglutarate<br />
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**[[5op6]], [[5op8]], [[5opc]] - hFIH1α + inhibitor<br />
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**[[3kcx]], [[3kcy]], [[3od4]], [[4bio]] - hFIH1α + quinol derivative<br />
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**[[4ai8]] - hFIH1α + daminozide<br />
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**[[4z1v]] - hFIH1α + oxalylglycine + NO<br />
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[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br />
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*FIH1α complex with polypeptide
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[[2ilm]], [[3d8c]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br />
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[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br />
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[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br />
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[[2y0i]] - hFIH1α + tankyrase 2 peptide<br />
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[[3hqr]], [[3hqu]] - hFIH 1α C terminal + EGL nine homolog<br />
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[[1lqb]], [[1lm8]] - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL<br />
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[[1l3e]] - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR<br />
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[[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger
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===FIH2α===
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**[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br />
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**[[2ilm]], [[3d8c]], [[5jwp]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br />
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**[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br />
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**[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br />
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**[[2y0i]] - hFIH1α + tankyrase 2 peptide<br />
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**[[3hqr]], [[3hqu]] - hFIH 1α C terminal + EGL nine homolog<br />
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**[[1lqb]], [[1lm8]] - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL<br />
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**[[1l3e]] - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR<br />
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**[[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger<br />
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**[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br />
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**[[4b7e]], [[4b7k]], [[4jaa]], [[4nr1]], [[7a1q]] - hFIH1α + consensus ankyrin repeat peptide<br />
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**[[7a1n]], [[7a1o]], [[7a1p]], [[7a1s]] - hFIH1α + consensus ankyrin repeat peptide + oxoglutarate derivative <br />
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**[[6h9j]], [[6ha6]] - hFIH1α + TRPV3 peptide + oxalylglycine<br />
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**[[6hc8]] - hFIH1α + TRPA1 peptide + oxalylglycine<br />
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**[[6hl6]] - hFIH1α + ASPP peptide + oxalylglycine<br />
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**[[6hl5]] - hFIH1α + ASPP1 peptide + oxalylglycine<br />
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**[[6hkp]] - hFIH1α + ASPP2 peptide + oxalylglycine<br />
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**[[6ruj]] - hFIH1α + ankyrin repeat + oxalylglycine<br />
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[[2a24]], [[3f1n]], [[3f1o]], [[3f1p]], [[3h7w]] - hFIH 2α PAS domain + hFIH 1β PAS domain<br />
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*FIH2α
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[[3h82]] - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
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===FIH1β===
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**[[2a24]], [[3f1n]], [[3f1o]], [[3f1p]], [[3h7w]] - hFIH 2α PAS domain + hFIH 1β PAS domain<br />
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**[[3h82]] - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
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[[2b02]], [[1x0o]] - hFIH 1β PAS domain<br />
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*FIH1β
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[[2hv1]], [[2k7s ]]- hFIH 1β PAS domain - NMR
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**[[2b02]], [[1x0o]] - hFIH 1β PAS domain<br />
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**[[2hv1]], [[2k7s ]]- hFIH 1β PAS domain - NMR<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Dimeric factor inhibiting HIF complex with oxogluterate derivative (PDB code 1mzf)

Drag the structure with the mouse to rotate

3D Structures of factor inhibiting HIF

Updated on 26-February-2023

References

  1. ↑ Janke K, Brockmeier U, Kuhlmann K, Eisenacher M, Nolde J, Meyer HE, Mairbaurl H, Metzen E. Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). J Cell Sci. 2013 Jun 15;126(Pt 12):2629-40. doi: 10.1242/jcs.117564. Epub 2013, Apr 19. PMID:23606740 doi:http://dx.doi.org/10.1242/jcs.117564
  2. ↑ Dann CE 3rd, Bruick RK, Deisenhofer J. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15351-6. Epub 2002 Nov 13. PMID:12432100 doi:http://dx.doi.org/10.1073/pnas.202614999

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Michal Harel, Alexander Berchansky

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