4a0r
From Proteopedia
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| - | [[Image:4a0r.png|left|200px]] | ||
| - | + | ==Structure of bifunctional DAPA aminotransferase-DTB synthetase from Arabidopsis thaliana bound to dethiobiotin (DTB).== | |
| + | <StructureSection load='4a0r' size='340' side='right'caption='[[4a0r]], [[Resolution|resolution]] 2.68Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4a0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A0R FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTB:6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC+ACID'>DTB</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0r OCA], [https://pdbe.org/4a0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a0r RCSB], [https://www.ebi.ac.uk/pdbsum/4a0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0r ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BIODA_ARATH BIODA_ARATH] Bifunctional enzyme that catalyzes two different reactions involved in the biotin biosynthesis. Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring. Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. | ||
| - | == | + | ==See Also== |
| - | + | *[[7%2C8-diaminopelargonic acid synthase 3D structures|7%2C8-diaminopelargonic acid synthase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Arabidopsis thaliana]] | [[Category: Arabidopsis thaliana]] | ||
| - | [[Category: Alban | + | [[Category: Large Structures]] |
| - | [[Category: Cobessi | + | [[Category: Alban C]] |
| - | [[Category: Dumas | + | [[Category: Cobessi D]] |
| - | [[Category: Ferrer | + | [[Category: Dumas R]] |
| - | [[Category: Meinguet | + | [[Category: Ferrer JL]] |
| - | [[Category: Pautre | + | [[Category: Meinguet C]] |
| - | + | [[Category: Pautre V]] | |
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Current revision
Structure of bifunctional DAPA aminotransferase-DTB synthetase from Arabidopsis thaliana bound to dethiobiotin (DTB).
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