1pbr

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[[Image:1pbr.jpg|left|200px]]<br /><applet load="1pbr" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1pbr" />
 
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'''STRUCTURE OF 16S RIBOSOMAL RNA, NMR, MINIMIZED AVERAGE STRUCTURE'''<br />
 
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==Overview==
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==STRUCTURE OF 16S RIBOSOMAL RNA, NMR, MINIMIZED AVERAGE STRUCTURE==
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Aminoglycoside antibiotics that bind to 30S ribosomal A-site RNA cause misreading of the genetic code and inhibit translocation. The aminoglycoside antibiotic paromomycin binds specifically to an RNA oligonucleotide that contains the 30S subunit A site, and the solution structure of the RNA-paromomycin complex was determined by nuclear magnetic resonance spectroscopy. The antibiotic binds in the major groove of the model A-site RNA within a pocket created by an A-A base pair and a single bulged adenine. Specific interactions occur between aminoglycoside chemical groups important for antibiotic activity and conserved nucleotides in the RNA. The structure explains binding of diverse aminoglycosides to the ribosome, their specific activity against prokaryotic organisms, and various resistance mechanisms, and provides insight into ribosome function.
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<StructureSection load='1pbr' size='340' side='right'caption='[[1pbr]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1pbr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PBR FirstGlance]. <br>
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1PBR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=PA1:'>PA1</scene>, <scene name='pdbligand=IDG:'>IDG</scene>, <scene name='pdbligand=PA2:'>PA2</scene> and <scene name='pdbligand=PA3:'>PA3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBR OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BDR:BETA-D-RIBOFURANOSYL'>BDR</scene>, <scene name='pdbligand=CYY:2-DEOXYSTREPTAMINE'>CYY</scene>, <scene name='pdbligand=IDG:O-2,6-DIAMINO-2,6-DIDEOXY-BETA-L-IDOPYRANOSE'>IDG</scene>, <scene name='pdbligand=PA1:2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSE'>PA1</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pbr OCA], [https://pdbe.org/1pbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pbr RCSB], [https://www.ebi.ac.uk/pdbsum/1pbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pbr ProSAT]</span></td></tr>
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Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic., Fourmy D, Recht MI, Blanchard SC, Puglisi JD, Science. 1996 Nov 22;274(5291):1367-71. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8910275 8910275]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Blanchard, S.]]
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</StructureSection>
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[[Category: Fourmy, D.]]
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[[Category: Large Structures]]
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[[Category: Puglisi, J D.]]
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[[Category: Blanchard S]]
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[[Category: Recht, M I.]]
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[[Category: Fourmy D]]
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[[Category: IDG]]
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[[Category: Puglisi JD]]
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[[Category: PA1]]
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[[Category: Recht MI]]
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[[Category: PA2]]
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[[Category: PA3]]
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[[Category: aminoglycoside]]
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[[Category: antibiotic]]
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[[Category: ribonucleic acid]]
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[[Category: ribosomal rna]]
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[[Category: rna transcript]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:27:13 2008''
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Current revision

STRUCTURE OF 16S RIBOSOMAL RNA, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1pbr

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