2ly4
From Proteopedia
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| - | [[Image:2ly4.jpg|left|200px]] | ||
| - | + | ==HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail== | |
| + | <StructureSection load='2ly4' size='340' side='right'caption='[[2ly4]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2ly4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LY4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ly4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ly4 OCA], [https://pdbe.org/2ly4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ly4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ly4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ly4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HMGB1_HUMAN HMGB1_HUMAN] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). | ||
| - | == | + | ==See Also== |
| - | + | *[[High mobility group protein|High mobility group protein]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | [[ | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Rowell | + | [[Category: Large Structures]] |
| - | [[Category: Simpson | + | [[Category: Rowell JP]] |
| - | [[Category: Stott | + | [[Category: Simpson KL]] |
| - | [[Category: Thomas | + | [[Category: Stott K]] |
| - | [[Category: Watson | + | [[Category: Thomas JO]] |
| - | + | [[Category: Watson M]] | |
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Current revision
HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail
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