4fbn
From Proteopedia
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| - | [[Image:4fbn.jpg|left|200px]] | ||
| - | + | ==Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains== | |
| + | <StructureSection load='4fbn' size='340' side='right'caption='[[4fbn]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fbn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FBN FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbn OCA], [https://pdbe.org/4fbn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fbn RCSB], [https://www.ebi.ac.uk/pdbsum/4fbn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fbn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PLCG1_HUMAN PLCG1_HUMAN] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.<ref>PMID:17229814</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Phospholipase C|Phospholipase C]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Bunney | + | [[Category: Bunney TD]] |
| - | [[Category: Cole | + | [[Category: Cole AR]] |
| - | [[Category: Katan | + | [[Category: Katan M]] |
| - | [[Category: Mas-Droux | + | [[Category: Mas-Droux CP]] |
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Current revision
Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains
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