3zua
From Proteopedia
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| - | [[Image:3zua.png|left|200px]] | ||
| - | + | ==A C39-like domain== | |
| + | <StructureSection load='3zua' size='340' side='right'caption='[[3zua]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3zua]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZUA FirstGlance]. <br> | ||
| + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Papain Papain], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zua OCA], [https://pdbe.org/3zua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zua RCSB], [https://www.ebi.ac.uk/pdbsum/3zua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zua ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/HLYB3_ECOLX HLYB3_ECOLX]] Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Type 1 secretion systems (T1SS) catalyze the one step protein transport across the membranes of Gram-negative bacteria and are composed of an outer membrane protein, a membrane fusion protein and an ABC transporter. The ABC transporter consists of the canonical nucleotide binding and transmembrane domains. For the toxin hemolysin A (HlyA), the ABC transporter HlyB carries an additional, N-terminal domain sharing about 40% homology to C39 peptidases, but this "C39-like domain" (CLD) is suggested to feature another, yet unknown function. Our functional and structural analysis demonstrates that the CLD is essential for secretion and that it specifically interacts with the unfolded state of HlyA. We determined the nuclear magnetic resonance structure of the CLD as well as the substrate-binding region within the CLD. This mode of action, represents a mechanism within T1SS and answers the question, how a large and unfolded substrate is protected inside the cells during secretion. | ||
| - | + | An RTX Transporter Tethers Its Unfolded Substrate during Secretion via a Unique N-Terminal Domain.,Lecher J, Schwarz CK, Stoldt M, Smits SH, Willbold D, Schmitt L Structure. 2012 Sep 5. PMID:22959622<ref>PMID:22959622</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 3zua" style="background-color:#fffaf0;"></div> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[ABC transporter 3D structures|ABC transporter 3D structures]] |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacillus coli migula 1895]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Papain]] | [[Category: Papain]] | ||
| - | [[Category: Lecher, J | + | [[Category: Lecher, J]] |
| - | [[Category: Schmitt, L | + | [[Category: Schmitt, L]] |
| - | [[Category: Schwarz, C K.W | + | [[Category: Schwarz, C K.W]] |
| - | [[Category: Smits, S S.H | + | [[Category: Smits, S S.H]] |
| - | [[Category: Stoldt, M | + | [[Category: Stoldt, M]] |
| - | [[Category: Willbold, D | + | [[Category: Willbold, D]] |
[[Category: Abc transporter]] | [[Category: Abc transporter]] | ||
[[Category: C39 peptidase-like domain]] | [[Category: C39 peptidase-like domain]] | ||
Current revision
A C39-like domain
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