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1pl2

From Proteopedia

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[[Image:1pl2.gif|left|200px]]<br /><applet load="1pl2" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1pl2, resolution 1.80&Aring;" />
 
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'''Crystal structure of human glutathione transferase (GST) A1-1 T68E mutant in complex with decarboxy-glutathione'''<br />
 
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==About this Structure==
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==Crystal structure of human glutathione transferase (GST) A1-1 T68E mutant in complex with decarboxy-glutathione==
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1PL2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=ABY:'>ABY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL2 OCA].
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<StructureSection load='1pl2' size='340' side='right'caption='[[1pl2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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[[Category: Glutathione transferase]]
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== Structural highlights ==
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[[Category: Homo sapiens]]
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<table><tr><td colspan='2'>[[1pl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PL2 FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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[[Category: Grahn, E.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABY:N-(4-AMINOBUTANOYL)-S-(4-METHOXYBENZYL)-L-CYSTEINYLGLYCINE'>ABY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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[[Category: Grehn, L.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl2 OCA], [https://pdbe.org/1pl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pl2 RCSB], [https://www.ebi.ac.uk/pdbsum/1pl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl2 ProSAT]</span></td></tr>
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[[Category: Gustafsson, A.]]
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</table>
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[[Category: Jakobsson, E.]]
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== Function ==
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[[Category: Kleywegt, G J.]]
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[https://www.uniprot.org/uniprot/GSTA1_HUMAN GSTA1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:20606271</ref>
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[[Category: Madsen, D.]]
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== Evolutionary Conservation ==
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[[Category: Mannervik, B.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Olin, B.]]
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Check<jmol>
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[[Category: Wahlberg, M.]]
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<jmolCheckbox>
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[[Category: ABY]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/1pl2_consurf.spt"</scriptWhenChecked>
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[[Category: CL]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: domain1:alpha-beta]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: domain2: alpha-helical]]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pl2 ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:29:54 2008''
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Grahn E]]
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[[Category: Grehn L]]
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[[Category: Gustafsson A]]
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[[Category: Jakobsson E]]
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[[Category: Kleywegt GJ]]
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[[Category: Madsen D]]
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[[Category: Mannervik B]]
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[[Category: Olin B]]
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[[Category: Wahlberg M]]

Current revision

Crystal structure of human glutathione transferase (GST) A1-1 T68E mutant in complex with decarboxy-glutathione

PDB ID 1pl2

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