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1pkz
From Proteopedia
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| - | [[Image:1pkz.gif|left|200px]]<br /><applet load="1pkz" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1pkz, resolution 2.10Å" /> | ||
| - | '''Crystal structure of human glutathione transferase (GST) A1-1'''<br /> | ||
| - | == | + | ==Crystal structure of human glutathione transferase (GST) A1-1== |
| - | + | <StructureSection load='1pkz' size='340' side='right'caption='[[1pkz]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[1pkz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PKZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene></td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkz OCA], [https://pdbe.org/1pkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pkz RCSB], [https://www.ebi.ac.uk/pdbsum/1pkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pkz ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | + | == Function == | |
| - | [ | + | [https://www.uniprot.org/uniprot/GSTA1_HUMAN GSTA1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:20606271</ref> |
| - | [[ | + | == Evolutionary Conservation == |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | [ | + | <jmolCheckbox> |
| - | [[ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/1pkz_consurf.spt"</scriptWhenChecked> |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pkz ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Grahn E]] | ||
| + | [[Category: Grehn L]] | ||
| + | [[Category: Gustafsson A]] | ||
| + | [[Category: Jakobsson E]] | ||
| + | [[Category: Kleywegt GJ]] | ||
| + | [[Category: Madsen D]] | ||
| + | [[Category: Mannervik B]] | ||
| + | [[Category: Olin B]] | ||
| + | [[Category: Wahlberg M]] | ||
Current revision
Crystal structure of human glutathione transferase (GST) A1-1
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Categories: Homo sapiens | Large Structures | Grahn E | Grehn L | Gustafsson A | Jakobsson E | Kleywegt GJ | Madsen D | Mannervik B | Olin B | Wahlberg M
