1pls

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[[Image:1pls.gif|left|200px]]<br /><applet load="1pls" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1pls" />
 
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'''SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN'''<br />
 
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==Overview==
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==SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN==
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Pleckstrin, the major protein kinase C substrate of platelets, contains domains of about 100 amino acids at the amino and carboxy termini that have been found in a number of proteins, including serine/threonine kinases, GTPase-activating proteins, phospholipases and cytoskeletal proteins. These conserved sequences, termed pleckstrin-homology (PH) domains, are thought to be involved in signal transduction. But the details of the function and binding partners of the PH domains have not been characterized. Here we report the solution structure of the N-terminal pleckstrin-homology domain of pleckstrin determined using heteronuclear three-dimensional nuclear magnetic resonance spectroscopy. The structure consists of an up-and-down beta-barrel of seven antiparallel beta-strands and a C-terminal amphiphilic alpha-helix that caps one end of the barrel. The overall topology of the domain is similar to that of the retinol-binding protein family of structures.
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<StructureSection load='1pls' size='340' side='right'caption='[[1pls]]' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[1pls]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PLS FirstGlance]. <br>
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Known disease associated with this structure: Age-related maculopathy, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607772 607772]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pls OCA], [https://pdbe.org/1pls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pls RCSB], [https://www.ebi.ac.uk/pdbsum/1pls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pls ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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1PLS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PLS OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/PLEK_HUMAN PLEK_HUMAN] Major protein kinase C substrate of platelets.
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==Reference==
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== Evolutionary Conservation ==
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Solution structure of a pleckstrin-homology domain., Yoon HS, Hajduk PJ, Petros AM, Olejniczak ET, Meadows RP, Fesik SW, Nature. 1994 Jun 23;369(6482):672-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8208296 8208296]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/1pls_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pls ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Fesik, S W.]]
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[[Category: Fesik SW]]
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[[Category: Hajduk, P J.]]
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[[Category: Hajduk PJ]]
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[[Category: Meadows, R P.]]
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[[Category: Meadows RP]]
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[[Category: Olejniczak, E T.]]
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[[Category: Olejniczak ET]]
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[[Category: Petros, A M.]]
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[[Category: Petros AM]]
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[[Category: Yoon, H S.]]
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[[Category: Yoon HS]]
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[[Category: phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:30:10 2008''
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Current revision

SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN

PDB ID 1pls

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