1dvp

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[[Image:1dvp.png|left|200px]]
 
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{{STRUCTURE_1dvp| PDB=1dvp | SCENE= }}
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==CRYSTAL STRUCTURE OF THE VHS AND FYVE TANDEM DOMAINS OF HRS, A PROTEIN INVOLVED IN MEMBRANE TRAFFICKING AND SIGNAL TRANSDUCTION==
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<StructureSection load='1dvp' size='340' side='right'caption='[[1dvp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THE VHS AND FYVE TANDEM DOMAINS OF HRS, A PROTEIN INVOLVED IN MEMBRANE TRAFFICKING AND SIGNAL TRANSDUCTION===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dvp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DVP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10693761}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dvp OCA], [https://pdbe.org/1dvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dvp RCSB], [https://www.ebi.ac.uk/pdbsum/1dvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dvp ProSAT]</span></td></tr>
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[[1dvp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DVP OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/HRS_DROME HRS_DROME] Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.<ref>PMID:11832215</ref>
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<ref group="xtra">PMID:010693761</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dv/1dvp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dvp ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Bellen, H.]]
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[[Category: Large Structures]]
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[[Category: Duan, X.]]
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[[Category: Bellen H]]
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[[Category: Lloyd, T E.]]
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[[Category: Duan X]]
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[[Category: Mao, Y.]]
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[[Category: Lloyd TE]]
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[[Category: Nickitenko, A.]]
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[[Category: Mao Y]]
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[[Category: Quiocho, F A.]]
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[[Category: Nickitenko A]]
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[[Category: Wu, M N.]]
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[[Category: Quiocho FA]]
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[[Category: Fyve]]
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[[Category: Wu MN]]
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[[Category: Hr]]
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[[Category: Superhelix]]
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[[Category: Transferase]]
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[[Category: Vh]]
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[[Category: Zinc finger]]
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Current revision

CRYSTAL STRUCTURE OF THE VHS AND FYVE TANDEM DOMAINS OF HRS, A PROTEIN INVOLVED IN MEMBRANE TRAFFICKING AND SIGNAL TRANSDUCTION

PDB ID 1dvp

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