1pmi

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[[Image:1pmi.gif|left|200px]]<br /><applet load="1pmi" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1pmi, resolution 1.7&Aring;" />
 
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'''HUMAN RANTES'''<br />
 
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==Overview==
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==Candida Albicans Phosphomannose Isomerase==
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Phosphomannose isomerase (PMI) catalyses the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P). Absence of PMI activity in yeasts causes cell lysis and thus the enzyme is a potential target for inhibition and may be a route to antifungal drugs. The 1.7 A crystal structure of PMI from Candida albicans shows that the enzyme has three distinct domains. The active site lies in the central domain, contains a single essential zinc atom, and forms a deep, open cavity of suitable dimensions to contain M6P or F6P The central domain is flanked by a helical domain on one side and a jelly-roll like domain on the other.
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<StructureSection load='1pmi' size='340' side='right'caption='[[1pmi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1pmi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PMI FirstGlance]. <br>
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1PMI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mannose-6-phosphate_isomerase Mannose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.8 5.3.1.8] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PMI OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pmi OCA], [https://pdbe.org/1pmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pmi RCSB], [https://www.ebi.ac.uk/pdbsum/1pmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pmi ProSAT]</span></td></tr>
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The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution., Cleasby A, Wonacott A, Skarzynski T, Hubbard RE, Davies GJ, Proudfoot AE, Bernard AR, Payton MA, Wells TN, Nat Struct Biol. 1996 May;3(5):470-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8612079 8612079]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MPI_CANAL MPI_CANAL] Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pm/1pmi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pmi ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Candida albicans]]
[[Category: Candida albicans]]
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[[Category: Mannose-6-phosphate isomerase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Bernard AR]]
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[[Category: Bernard, A R.]]
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[[Category: Cleasby A]]
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[[Category: Cleasby, A.]]
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[[Category: Davies GJ]]
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[[Category: Davies, G J.]]
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[[Category: Hubbard RE]]
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[[Category: Hubbard, R E.]]
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[[Category: Payton MA]]
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[[Category: Payton, M A.]]
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[[Category: Proudfoot AEI]]
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[[Category: Proudfoot, A E.I.]]
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[[Category: Skarzynski T]]
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[[Category: Skarzynski, T.]]
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[[Category: Wells TNC]]
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[[Category: Wells, T N.C.]]
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[[Category: Wonacott A]]
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[[Category: Wonacott, A.]]
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[[Category: ZN]]
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[[Category: aldose-ketose isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:30:17 2008''
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Current revision

Candida Albicans Phosphomannose Isomerase

PDB ID 1pmi

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