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1bhs

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[[Image:1bhs.gif|left|200px]]<br />
 
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<applet load="1bhs" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bhs, resolution 2.20&Aring;" />
 
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'''HUMAN ESTROGENIC 17BETA-HYDROXYSTEROID DEHYDROGENASE'''<br />
 
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==Overview==
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==HUMAN ESTROGENIC 17BETA-HYDROXYSTEROID DEHYDROGENASE==
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BACKGROUND: The principal human estrogen, 17 beta-estradiol, is a potent, stimulator of certain endocrine-dependent forms of breast cancer. Because, human estrogenic 17 beta-hydroxysteroid dehydrogenase (type I 17 beta-HSD), catalyzes the last step in the biosynthesis of 17 beta-estradiol from the, less potent estrogen, estrone, it is an attractive target for the design, of inhibitors of estrogen production and tumor growth. This human enzyme, shares less than 15% sequence identity with a bacterial 3 alpha,20, beta-HSD, for which the three-dimensional structure is known. The amino, acid sequence of 17 beta-HSD also differs from that of bacterial 3, alpha,20 beta-HSD by two insertions (of 11 and 14 residues) and 52, additional residues at the C terminus. RESULTS: The 2.20 A resolution, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?7663947 (full description)]]
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<StructureSection load='1bhs' size='340' side='right'caption='[[1bhs]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BHS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bhs OCA], [https://pdbe.org/1bhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bhs RCSB], [https://www.ebi.ac.uk/pdbsum/1bhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bhs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DHB1_HUMAN DHB1_HUMAN] Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bh/1bhs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bhs ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1BHS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Estradiol_17-beta-dehydrogenase Estradiol 17-beta-dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62]]. Structure known Active Site: CAT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BHS OCA]].
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution., Ghosh D, Pletnev VZ, Zhu DW, Wawrzak Z, Duax WL, Pangborn W, Labrie F, Lin SX, Structure. 1995 May 15;3(5):503-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7663947 7663947]
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[[Category: Estradiol 17-beta-dehydrogenase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ghosh, D.]]
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[[Category: Ghosh D]]
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[[Category: estrogen]]
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[[Category: human placental 17beta-hsd]]
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[[Category: human type i 17beta-hsd]]
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[[Category: oxidoreductase]]
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[[Category: short-chain dehydrogenase]]
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[[Category: steroid dehydrogenase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:54:57 2007''
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Current revision

HUMAN ESTROGENIC 17BETA-HYDROXYSTEROID DEHYDROGENASE

PDB ID 1bhs

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