Granzyme

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<StructureSection load='1fq3' size='400' side='right' caption='Structure of human granzyme A complex with sulfate (PDB entry [[1fq3]])' scene=''>
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<StructureSection load='1iau' size='400' side='right' caption='Structure of glycosylated human granzyme B (green) complex with pentapeptide inhibitor (magenta) and Zn+2 ions (grey) (PDB entry [[1iau]])' scene='51/517375/Cv/1'>
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== Function ==
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'''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells<ref>PMID:17158907</ref>.<br />
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*'''Granzyme A''' is the most abundant serine protease in killer cells cytotoxic granules <ref>PMID:20536557</ref>.<br />
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*'''Granzyme B and C''' induce cytotoxic T lymphocyte-mediated target cell apoptosis <ref>PMID:12752668</ref>.<br />
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*'''Granzyme H''' helps granzyme B kill adenovirus-infected cells <ref>PMID:17766182</ref>.<br />
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*'''Granzyme K''' functions in a similar way to granzyme A <ref>PMID:19059912</ref>.<br />
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*'''Granzyme M''' induces target cell death, inhibits viral replication and regulates inflammation <ref>PMID:24413154</ref>.<br />
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'''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells.
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== Structural highlights ==
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The <scene name='51/517375/Cv/6'>active site</scene> of human GZMB contains the <scene name='51/517375/Cv/7'>typical serine protease catalytic triad</scene> and <scene name='51/517375/Cv/8'>oxyanion hole</scene><ref>PMID:11325591</ref>.
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</StructureSection>
==3D structures of granzyme==
==3D structures of granzyme==
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===Granzyme A===
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1op8]] – hGZM<br />
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*Granzyme A
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[[1orf]] – hGZM (mutant)
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===Granzyme B===
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**[[1op8]] – hGZM<br />
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**[[1orf]] – hGZM (mutant)
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[[1fi8]] – GZM (mutant) + ecotin – rat<br />
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*Granzyme B
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[[1fq3]] – hGZM<br />
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[[1iau]] – hGZM + polypeptide<br />
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===Granzyme C===
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**[[1fi8]] – GZM (mutant) + ecotin – rat<br />
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**[[1fq3]] – hGZM<br />
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**[[1iau]] – hGZM + polypeptide<br />
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[[3fzz]] – mGZM – mouse<br />
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*Granzyme C
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[[3g01]] – mGZM (mutant)
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===Granzyme H===
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**[[3fzz]] – mGZM – mouse<br />
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**[[3g01]] – mGZM (mutant)
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[[3tk9]] - hGZM (mutant) <br />
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*Granzyme H
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[[3tju]], [[3tjv]] - hGZM (mutant) + polypeptide<br />
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===Granzyme K===
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**[[4gaw]] – hGZM<br />
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**[[3tk9]] - hGZM (mutant) <br />
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**[[3tju]], [[3tjv]] - hGZM (mutant) + polypeptide<br />
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[[1mza]], [[1mzd]] – h-proGZM (mutant)
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*Granzyme K
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===Granzyme M===
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**[[1mza]], [[1mzd]] – h-proGZM (mutant)
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[[2zgc]] – hGZM<br />
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*Granzyme M
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[[2zgh]], [[2zks]] - hGZM + polypeptide<br />
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[[2zgj]] – hGZM (mutant) + polypeptide<br />
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**[[2zgc]] – hGZM<br />
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**[[2zgh]], [[2zks]] - hGZM + polypeptide<br />
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**[[2zgj]] – hGZM (mutant) + polypeptide<br />
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}}
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== References ==
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<references/>
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[[Category:Topic Page]]
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</StructureSection>
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Current revision

Structure of glycosylated human granzyme B (green) complex with pentapeptide inhibitor (magenta) and Zn+2 ions (grey) (PDB entry 1iau)

Drag the structure with the mouse to rotate

3D structures of granzyme

Updated on 04-April-2019

References

  1. ↑ Bots M, Medema JP. Granzymes at a glance. J Cell Sci. 2006 Dec 15;119(Pt 24):5011-4. PMID:17158907 doi:http://dx.doi.org/10.1242/jcs.03239
  2. ↑ Lieberman J. Granzyme A activates another way to die. Immunol Rev. 2010 May;235(1):93-104. doi: 10.1111/j.0105-2896.2010.00902.x. PMID:20536557 doi:http://dx.doi.org/10.1111/j.0105-2896.2010.00902.x
  3. ↑ Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC. Granzyme B: a natural born killer. Immunol Rev. 2003 Jun;193:31-8. PMID:12752668
  4. ↑ Waterhouse NJ, Trapani JA. H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. Trends Immunol. 2007 Sep;28(9):373-5. Epub 2007 Sep 4. PMID:17766182 doi:http://dx.doi.org/10.1016/j.it.2007.08.001
  5. ↑ Bovenschen N, Quadir R, van den Berg AL, Brenkman AB, Vandenberghe I, Devreese B, Joore J, Kummer JA. Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A. J Biol Chem. 2009 Feb 6;284(6):3504-12. doi: 10.1074/jbc.M806716200. Epub 2008, Dec 5. PMID:19059912 doi:http://dx.doi.org/10.1074/jbc.M806716200
  6. ↑ de Poot SA, Bovenschen N. Granzyme M: behind enemy lines. Cell Death Differ. 2014 Mar;21(3):359-68. doi: 10.1038/cdd.2013.189. Epub 2014, Jan 10. PMID:24413154 doi:http://dx.doi.org/10.1038/cdd.2013.189
  7. ↑ Rotonda J, Garcia-Calvo M, Bull HG, Geissler WM, McKeever BM, Willoughby CA, Thornberry NA, Becker JW. The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1. Chem Biol. 2001 Apr;8(4):357-68. PMID:11325591

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