Nuclear receptor coactivator

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{{STRUCTURE_1oj5| PDB=1oj5 | SIZE=400| SCENE= |right|CAPTION=Mouse nuclear receptor activator (grey) complex with STAT6 transactivator domain LXXLL peptide (green) and I-1 ions, [[1oj5]] }}
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<StructureSection load='' size='350' side='right' scene='49/494427/Cv/1' caption='Mouse nuclear receptor activator (green) complex with STAT6 transactivator domain LXXLL peptide (sky blue) and I-1 ions, [[1oj5]]'>
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'''Nuclear receptor coactivator''' (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA are involved in coactivation with transcription factors. NCOA1 shows histone acetyltransferase activity and is required for steroid hormone response. NCOA2 is a DNA transcription coactivator with glucocorticoid receptor. NCOA3 shows histone acetyltransferase activity.
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'''Nuclear receptor coactivator''' (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors<ref>PMID:9121485</ref>.<br />
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*'''NCOA1''' shows histone acetyltransferase activity and is required for steroid hormone response.<br />
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*'''NCOA2''' is a DNA transcription coactivator with glucocorticoid receptor.<br />
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*'''NCOA3''' shows histone acetyltransferase activity.<br />
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*'''NCOA5''' is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.<br />
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*'''NCOA7''' may be a driver for beast cancer metastasis<ref>PMID:38699661</ref><br />
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See also: [[Glucocorticoids]] and [[Steroid Hormones and their receptors]].<br />.
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== Structural highlights ==
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*<scene name='49/494427/Cv/7'>NCOA/STAT6 transactivator domain LXXLL peptide interactions</scene>.
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*<scene name='49/494427/Cv/8'>1st Iod coordination site</scene>.
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*<scene name='49/494427/Cv/9'>2nd Iod coordination site</scene>. Water molecules are shown as red spheres.
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*<scene name='49/494427/Cv/10'>3th and 4th Iod coordination sites</scene>.
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*<scene name='49/494427/Cv/11'>5th Iod coordination site</scene>.
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</StructureSection>
==3D structures of nuclear receptor coactivator==
==3D structures of nuclear receptor coactivator==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[1v95]] – hNCOA5 – human - NMR<br />
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[[2c52]] – hNCOA1 residues 920-970 + CREB-binding protein – human<br />
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[[1kbh]] – hNCOA + CREB-binding protein - NMR<br />
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[[1kbh]], [[6es7]], [[6sqc]] – hNCOA3 1040-1086 + CREB-binding protein – NMR<br />
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[[2c52]] – hNCOA1 residues 920-970 + CREB-binding protein - NMR<br />
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[[1v95]] – hNCOA5 anticodon binding domain 197-313 – human – NMR<br />
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[[1oj5]] – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse
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[[8arp]] – hNCOA7 781-942 <br />
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[[1oj5]] – mNCOA1A Pas-B domain 257-367 + signal transducer and activator of transcription peptide – mouse<br />
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[[5y7w]] - mNCOA1A Pas-B domain + YL-2 peptide<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Mouse nuclear receptor activator (green) complex with STAT6 transactivator domain LXXLL peptide (sky blue) and I-1 ions, 1oj5

Drag the structure with the mouse to rotate

3D structures of nuclear receptor coactivator

Updated on 17-July-2024

2c52 – hNCOA1 residues 920-970 + CREB-binding protein – human
1kbh, 6es7, 6sqc – hNCOA3 1040-1086 + CREB-binding protein – NMR
1v95 – hNCOA5 anticodon binding domain 197-313 – human – NMR
8arp – hNCOA7 781-942
1oj5 – mNCOA1A Pas-B domain 257-367 + signal transducer and activator of transcription peptide – mouse
5y7w - mNCOA1A Pas-B domain + YL-2 peptide

References

  1. ↑ Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:http://dx.doi.org/10.1210/mend.10.10.9121485
  2. ↑ Peng Z, Li Y, Xia S, Dai Q, Yin L, Chen M, Yang W, Shao G, Lin Q. Expression of nuclear receptor co‑activator 7 protein is associated with poor prognosis of breast cancer. Oncol Lett. 2024 Apr 23;27(6):278. PMID:38699661 doi:10.3892/ol.2024.14411

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