2yps
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2yps is ON HOLD Authors: Canning, P., Kiyani, W., Froese, D.S., Krojer, T., Strain-Damerell, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bou...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the PX domain of human sorting nexin 3== | |
| + | <StructureSection load='2yps' size='340' side='right'caption='[[2yps]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2yps]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YPS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yps OCA], [https://pdbe.org/2yps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yps RCSB], [https://www.ebi.ac.uk/pdbsum/2yps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yps ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN] MMEP syndrome. The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving SNX3 has been found in patients with syndromic microphthalmia. Translocation t(6;13)(q21;q12). | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN] Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation.<ref>PMID:11433298</ref> <ref>PMID:18767904</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Sorting nexin 3D structures|Sorting nexin 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Canning P]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Froese DS]] | ||
| + | [[Category: Kiyani W]] | ||
| + | [[Category: Krojer T]] | ||
| + | [[Category: Strain-Damerell C]] | ||
| + | [[Category: Yue WW]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of the PX domain of human sorting nexin 3
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Canning P | Edwards AM | Froese DS | Kiyani W | Krojer T | Strain-Damerell C | Yue WW | Von Delft F
