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4bd8

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'''Unreleased structure'''
 
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The entry 4bd8 is ON HOLD until Paper Publication
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==Bax domain swapped dimer induced by BimBH3 with CHAPS==
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<StructureSection load='4bd8' size='340' side='right'caption='[[4bd8]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4bd8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BD8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bd8 OCA], [https://pdbe.org/4bd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bd8 RCSB], [https://www.ebi.ac.uk/pdbsum/4bd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bd8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
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Authors: Czabotar, P.E., Westphal, D., Adams, J.M., Colman, P.M.
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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Description:
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Adams JM]]
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[[Category: Colman PM]]
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[[Category: Czabotar PE]]
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[[Category: Westphal D]]

Current revision

Bax domain swapped dimer induced by BimBH3 with CHAPS

PDB ID 4bd8

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