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4e3k

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[[Image:4e3k.png|left|200px]]
 
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{{STRUCTURE_4e3k| PDB=4e3k | SCENE= }}
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==Crystal structure of AmpC beta-lactamase in complex with a designed 4-tetrazolyl pyridine sulfonamide boronic acid inhibitor==
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<StructureSection load='4e3k' size='340' side='right'caption='[[4e3k]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4e3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E3K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4299&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0NA:[({[6-(1H-TETRAZOL-5-YL)PYRIDIN-3-YL]SULFONYL}AMINO)METHYL]BORONIC+ACID'>0NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e3k OCA], [https://pdbe.org/4e3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e3k RCSB], [https://www.ebi.ac.uk/pdbsum/4e3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e3k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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===Crystal structure of AmpC beta-lactamase in complex with a designed 4-tetrazolyl pyridine sulfonamide boronic acid inhibitor===
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4e3k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3K OCA].
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[[Category: Escherichia coli K-12]]
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
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[[Category: Escherichia coli k-12]]
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[[Category: Eidam O]]
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[[Category: Eidam, O.]]
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[[Category: Shoichet BK]]
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[[Category: Shoichet, B K.]]
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[[Category: Ampc beta-lactamase]]
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[[Category: Cephalosporinase]]
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[[Category: Class c]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Crystal structure of AmpC beta-lactamase in complex with a designed 4-tetrazolyl pyridine sulfonamide boronic acid inhibitor

PDB ID 4e3k

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