3j2i

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[[Image:3j2i.jpg|left|200px]]
 
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{{STRUCTURE_3j2i| PDB=3j2i | SCENE= }}
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==Structure of late pre-60S ribosomal subunits with nuclear export factor Arx1 bound at the peptide exit tunnel==
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<SX load='3j2i' size='340' side='right' viewer='molstar' caption='[[3j2i]], [[Resolution|resolution]] 11.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3j2i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J2I FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 11.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j2i OCA], [https://pdbe.org/3j2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j2i RCSB], [https://www.ebi.ac.uk/pdbsum/3j2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j2i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2G4_HUMAN PA2G4_HUMAN] May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity).<ref>PMID:11268000</ref> <ref>PMID:12682367</ref> <ref>PMID:15064750</ref> <ref>PMID:15583694</ref>
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===Structure of late pre-60S ribosomal subunits with nuclear export factor Arx1 bound at the peptide exit tunnel===
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3j2i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J2I OCA].
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__TOC__
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</SX>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Large Structures]]
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[[Category: Beckmann, R.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Boettcher, B.]]
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[[Category: Beckmann R]]
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[[Category: Bradatsch, B.]]
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[[Category: Boettcher B]]
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[[Category: Gnaedig, M.]]
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[[Category: Bradatsch B]]
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[[Category: Granneman, S.]]
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[[Category: Gnaedig M]]
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[[Category: Hurt, E.]]
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[[Category: Granneman S]]
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[[Category: Leidig, C.]]
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[[Category: Hurt E]]
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[[Category: Tollervey, D.]]
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[[Category: Leidig C]]
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[[Category: Cryo-em]]
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[[Category: Tollervey D]]
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[[Category: Pre-ribosome]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosome]]
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[[Category: Signaling protein]]
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Current revision

Structure of late pre-60S ribosomal subunits with nuclear export factor Arx1 bound at the peptide exit tunnel

3j2i, resolution 11.90Å

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