4hmb
From Proteopedia
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| - | [[Image:4hmb.jpg|left|200px]] | ||
| - | { | + | ==Crystal Structure of the complex of group II phospholipase A2 with a 3-{3-[(Dimethylamino)methyl]-1H-indol-7-yl}propan-1-ol at 2.21 A Resolution== |
| + | <StructureSection load='4hmb' size='340' side='right'caption='[[4hmb]], [[Resolution|resolution]] 2.21Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4hmb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_pulchella Daboia russelii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HMB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PZZ:3-{3-[(DIMETHYLAMINO)METHYL]-1H-INDOL-7-YL}PROPAN-1-OL'>PZZ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmb OCA], [https://pdbe.org/4hmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hmb RCSB], [https://www.ebi.ac.uk/pdbsum/4hmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hmb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref> | ||
| - | === | + | ==See Also== |
| - | + | *[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | [[ | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Chandra | + | [[Category: Daboia russelii pulchella]] |
| - | [[Category: Haridas | + | [[Category: Large Structures]] |
| - | [[Category: Kaur | + | [[Category: Chandra DN]] |
| - | [[Category: Sharma | + | [[Category: Haridas M]] |
| - | [[Category: Shukla | + | [[Category: Kaur P]] |
| - | [[Category: Singh | + | [[Category: Sharma S]] |
| - | [[Category: Sinha | + | [[Category: Shukla PK]] |
| - | + | [[Category: Singh TP]] | |
| - | + | [[Category: Sinha M]] | |
Current revision
Crystal Structure of the complex of group II phospholipase A2 with a 3-{3-[(Dimethylamino)methyl]-1H-indol-7-yl}propan-1-ol at 2.21 A Resolution
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