4ea4
From Proteopedia
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| - | [[Image:4ea4.png|left|200px]] | ||
| - | + | ==Structure of the glycosylase domain of MBD4 bound to 5hmU-containing DNA== | |
| + | <StructureSection load='4ea4' size='340' side='right'caption='[[4ea4]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ea4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EA4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5HU:5-HYDROXYMETHYLURIDINE-2-DEOXY-5-MONOPHOSPHATE'>5HU</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ea4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ea4 OCA], [https://pdbe.org/4ea4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ea4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ea4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ea4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | [[ | + | __TOC__ |
| - | + | </StructureSection> | |
| - | == | + | |
| - | < | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Morera S]] |
| - | [[Category: | + | [[Category: Vigouroux A]] |
| - | + | ||
Current revision
Structure of the glycosylase domain of MBD4 bound to 5hmU-containing DNA
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