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1enu
From Proteopedia
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| - | [[Image:1enu.png|left|200px]] | ||
| - | + | ==A new target for shigellosis: Rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase== | |
| + | <StructureSection load='1enu' size='340' side='right'caption='[[1enu]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1enu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ENU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ENU FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APZ:4-AMINOPHTHALHYDRAZIDE'>APZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1enu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1enu OCA], [https://pdbe.org/1enu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1enu RCSB], [https://www.ebi.ac.uk/pdbsum/1enu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1enu ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/en/1enu_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1enu ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | === | + | ==See Also== |
| - | + | *[[TRNA-guanine transglycosylase 3D structures|TRNA-guanine transglycosylase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[ | + | [[Category: Large Structures]] |
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[[Category: Zymomonas mobilis]] | [[Category: Zymomonas mobilis]] | ||
| - | + | [[Category: Ficner R]] | |
| - | [[Category: Ficner | + | [[Category: Garcia GA]] |
| - | [[Category: Garcia | + | [[Category: Gerber HD]] |
| - | [[Category: Gerber | + | [[Category: Goodenough-Lashua DM]] |
| - | [[Category: Goodenough-Lashua | + | [[Category: Gradler U]] |
| - | [[Category: Gradler | + | [[Category: Klebe G]] |
| - | [[Category: Klebe | + | [[Category: Reuter K]] |
| - | [[Category: Reuter | + | [[Category: Stubbs MT]] |
| - | [[Category: Stubbs | + | |
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Current revision
A new target for shigellosis: Rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase
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