Phosphoglucose isomerase

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{{STRUCTURE_1hox| PDB=1hox | SIZE=400| SCENE= |right|CAPTION=Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]] }}
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<StructureSection load='' size='350' side='right' scene='48/481605/Cv/2' caption='Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]]'>
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== Function ==
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'''Phosphoglucose isomerase''' (PGI) or '''glucose-6-phosphate isomerase''' catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate<ref>PMID:25811607</ref>. The encoded protein is also referred to as '''autocrine motility factor''' (AMF) based on an additional function as a '''tumor-secreted cytokine''' and '''angiogenic factor''' (see [[Growth factors]]). PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]].
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'''Phosphoglucose isomerase''' (PGI) catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate. PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]].
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{{TOC limit|limit=2}}
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== Disease ==
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Increased expression of PGI enhances colorectal cancer metastasis<ref>PMID:19787266</ref>.
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== Structural highlights ==
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Rabbit <scene name='48/481605/Cv/6'>PGI active site containing the substrate D-fructose 6-phosphate shows the substrate interacting mainly with residues of one subunit</scene><ref>PMID:11425306</ref>. Water molecules are shown as red spheres.
== 3D Structures of phosphoglucose isomerase ==
== 3D Structures of phosphoglucose isomerase ==
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[[Phosphoglucose isomerase 3D structures]]
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===PGI===
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</StructureSection>
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[[2pgi]], [[1b0z]] – GsPGI – ''Geobacillus stearothermophilus''<br />
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[[1dqr]], [[1hm5]], [[1n8t]] – rPGI – rabbit<br />
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[[1iat]], [[1jlh]] – hPGI – human<br />
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[[1qxj]], [[1x8e]], [[3sxw]] – PfPGI – ''Pyrococcus furiosus''<br />
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[[1j3p]], [[1j3q]] – TlPGI – ''Thermococcus litoralis''<br />
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[[1q50]] – LmPGI – ''Leishmania Mexicana''<br />
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[[1u0e]], [[2cvp]] – mPGI – mouse<br />
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[[2q8n]] – PGI – ''Thermotoga maritima''<br />
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[[3hjb]] – PGI – ''Vibrio cholera''<br />
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[[3ifs]] – PGI – ''Bacillus anthracis''<br />
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[[2wu8]] – PGI – ''Mycobacterium tuberculosis''<br />
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[[3ljk]] – FtPGI (mutant) – ''Francisella tularensis''<br />
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[[3nbu]] – PGI – ''Escherichia coli''
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===PGI complex with fructose-6-phosphate===
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[[1hox]] – rPGI + fructose-6-phosphate<br />
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[[1t10]] - LmPGI + fructose-6-phosphate<br />
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[[2gc2]] - PfPGI + fructose-6-phosphate<br />
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[[2cxs]], [[2cxt]] - mPGI + fructose-6-phosphate<br />
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[[3m5p]] - FtPGI (mutant) + fructose-6-phosphate<br />
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===PGI complex with sorbitol-6-phosphate===
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[[1xtb]] - rPGI + sorbitol-6-phosphate<br />
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[[2gc1]] - PfPGI + sorbitol-6-phosphate<br />
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[[2cxq]] - mPGI + sorbitol-6-phosphate<br />
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===PGI complex with phosphoarabinose===
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[[1gzd]], [[1gzv]] – PGI + phosphoarabinose – pig<br />
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[[1c7r]] - GsPGI + phosphoarabinose<br />
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[[2cxp]] – mPGI + phosphoarabinose<br />
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[[1nuh]] - hPGI + phosphoarabinose<br />
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[[1qsr]], [[1x7n]], [[1x82]] - PfPGI + phosphoarabinose<br />
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[[2gc0]] - PfPGI + phosphoarabinose derivative<br />
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[[1koj]] – rPGI + phosphoarabinose derivative
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===PGI complex with gluconate-6-phosphate===
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[[1qy4]] - PfPGI + gluconate-6-phosphate<br />
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[[1j3r]] - TlPGI + gluconate-6-phosphate<br />
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[[2cxr]] - mPGI + gluconate-6-phosphate<br />
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[[3q7i]] - FtPGI (mutant) + gluconate-6-phosphate<br />
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===PGI complex with glucose-6-phosphate===
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[[1u0f]] - mPGI + glucose-6-phosphate<br />
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[[3ff1]] - PGI + glucose-6-phosphate – ''Staphylococcus aureus''<br />
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[[2o2c]] - TbPGI + glucose-6-phosphate – ''Trypanosoma brucei''
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===Other PGI binary complexes===
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[[2o2d]] – TbPGI + citrate<br />
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[[1u0g]], [[2cxo]] - mPGI + erythrose-4-phosphate<br />
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[[3q88]] – FtPGI (mutant) + ribose bisphosphate<br />
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[[1c7q]] – GsPGI + phosphate inhibitor<br />
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[[2cxn]], [[2cxu]] – mPGI + phosphate<br />
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[[1g98]] – rPGI + transition state analog<br />
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[[2gc3]] - PfPGI + mannose-6-phosphate<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, 1hox

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References

  1. ↑ Bahaji A, Sanchez-Lopez AM, De Diego N, Munoz FJ, Baroja-Fernandez E, Li J, Ricarte-Bermejo A, Baslam M, Aranjuelo I, Almagro G, Humplik JF, Novak O, Spichal L, Dolezal K, Pozueta-Romero J. Plastidic phosphoglucose isomerase is an important determinant of starch accumulation in mesophyll cells, growth, photosynthetic capacity, and biosynthesis of plastidic cytokinins in Arabidopsis. PLoS One. 2015 Mar 26;10(3):e0119641. doi: 10.1371/journal.pone.0119641., eCollection 2015. PMID:25811607 doi:http://dx.doi.org/10.1371/journal.pone.0119641
  2. ↑ Tsutsumi S, Fukasawa T, Yamauchi H, Kato T, Kigure W, Morita H, Asao T, Kuwano H. Phosphoglucose isomerase enhances colorectal cancer metastasis. Int J Oncol. 2009 Nov;35(5):1117-21. PMID:19787266
  3. ↑ Lee JH, Chang KZ, Patel V, Jeffery CJ. Crystal structure of rabbit phosphoglucose isomerase complexed with its substrate D-fructose 6-phosphate. Biochemistry. 2001 Jul 3;40(26):7799-805. PMID:11425306

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