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Phosphomannomutase

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{{STRUCTURE_1pcj| PDB=1pcj | SIZE=400| SCENE= |right|CAPTION=Human Se-Met phosphomannomutase 1 complex with α-D-mannose-1-phosphate and Mg+2 ion, [[1pcj]] }}
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<StructureSection load='' size='350' side='right' caption='Human phosphomannomutase 1 complex with α-D-mannose-1-phosphate and Mg+2 ion (green) (PDB entry [[2fue]])' scene='48/481638/Cv/1'>
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== Function ==
'''Phosphomannomutase''' (PMM) catalyzes the conversion of α-D-mannose 1-phosphate to D-mannose 6-phosphate. PMM participates in fructose and mannose metabolism.
'''Phosphomannomutase''' (PMM) catalyzes the conversion of α-D-mannose 1-phosphate to D-mannose 6-phosphate. PMM participates in fructose and mannose metabolism.
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{{TOC limit|limit=2}}
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== Disease ==
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Mutations in PMM2 cause carbohydrate-deficient glycoprotein syndrome type 1 (Jaeken syndrome)<ref>PMID:9140401</ref>.
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== Structural highlights ==
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The PMM structure contains a <scene name='48/481638/Cv/7'>core domain and a cap domain</scene>. It is known that in order for the substrate to bind, the cap must dissociate from the core domain and then re-associate to seal the active site from solvent molecules. The <scene name='48/481638/Cv/8'>active site of PMM is located at the interface of the core and cap domains of the molecule</scene><ref>PMID:16540464</ref>. Water molecules are shown as red spheres.
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</StructureSection>
== 3D Structures of phosphomannomutase ==
== 3D Structures of phosphomannomutase ==
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===Phosphomannomutase===
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1k2y]] – PaPMM (mutant) – ''Pseudomonas aeruginosa''<br />
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*Phosphomannomutase
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[[1k35]] – PaPMM<br />
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[[2amy]], [[2q4r]] – hPMM2 – human<br />
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[[2fuc]] – hPMM1 + Mg<br />
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[[2i54]] – LmPMM + Mg – ''Leishmania Mexicana''<br />
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[[3f9r]] - PMM + Mg – ''Trypanosoma brucei''<br />
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[[2i55]] - LmPMM + α-D-glucose-1,6-bisphosphate + Mg<br />
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[[2fue]] – hPMM1 + α-D-mannose-1-phosphate + Mg<br />
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[[1p5d]], [[1p5g]] – PaPMM + α-D-glucose-1-phosphate<br />
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[[1pcj]], [[1pcm]] - PaPMM + α-D-mannose-1-phosphate<br />
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===Phosphomannomutase/Phosphoglucomutase complex===
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**[[2amy]], [[2q4r]] – hPMM2 – human<br />
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**[[2fuc]] – hPMM1 + Mg<br />
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**[[6cfr]], [[6cfs]], [[6cft]], [[6cfu]] – hPMM1 (mutant) + Mg<br />
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**[[6cfv]] – hPMM1 + Mg + inosine<br />
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**[[2fue]] – hPMM1 + α-D-mannose-1-phosphate + Mg<br />
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**[[7o0c]] – hPMM2 + Mg<br />
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**[[7o5z]] – hPMM2 (mutant) + Mg<br />
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**[[7o1b]], [[7o4g]], [[7o58]] – hPMM2 + α-D-glucose-1,6-bisphosphate + Mg<br />
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**[[2i54]] – LmPMM + Mg – ''Leishmania Mexicana''<br />
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**[[2i55]] - LmPMM + α-D-glucose-1,6-bisphosphate + Mg<br />
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**[[3f9r]] - PMM + Mg – ''Trypanosoma brucei''<br />
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**[[8b5v]] - PMM + Mg – ''Trypanosoma cruzi''<br />
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**[[6i5x]] – PMM + Mg – ''Aspergillus fumigata''<br />
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**[[1k35]] – PaPMM – ''Pseudomonas aeruginosa''<br />
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**[[1k2y]] – PaPMM (mutant)<br />
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**[[1p5d]], [[1p5g]] – PaPMM + α-D-glucose-1-phosphate<br />
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**[[4hjh]] - PaPMM + D-glucose-6-phosphate<br />
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**[[1pcj]], [[1pcm]] - PaPMM + α-D-mannose-1-phosphate<br />
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**[[5ue7]] - PMM – ''Candida albicans''<br />
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**[[7myv]] – PMM + Mg – ''Plasmodium falciparum''<br />
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[[1wqa]] – PMM/PGM + Mg – ''Pyrococcus horikoshii''<br />
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*Phosphomannomutase/Phosphoglucomutase complex
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[[2fkf]] - PaPMM/PGM + α-D-glucose-1,6-bisphosphate<br />
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[[2fkm]] - PaPMM/PGM (mutant) + α-D-glucose-1,6-bisphosphate<br />
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[[3bkq]] - PaPMM/PGM (mutant) + α-D-glucose-1-phosphate<br />
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[[3c04]] - PaPMM/PGM (mutant) <br />
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[[2h4l]] - PaPMM/PGM + ribose-1-phosphate<br />
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[[2h5a]] - PaPMM/PGM + xylose-1-phosphate<br />
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[[2f7l]] - PMM/PGM – ''Sulfolobus tokodaii''<br />
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[[3uw2]] – PMM/PGM PGM domain + phosphate – ''Burkholderia thailandensis''
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**[[1wqa]] – PMM/PGM + Mg – ''Pyrococcus horikoshii''<br />
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**[[2fkf]] - PaPMM/PGM + α-D-glucose-1,6-bisphosphate<br />
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**[[2fkm]] - PaPMM/PGM (mutant) + α-D-glucose-1,6-bisphosphate<br />
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**[[3bkq]] - PaPMM/PGM (mutant) + α-D-glucose-1-phosphate<br />
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**[[4mrq]] - PaPMM/PGM<br />
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**[[3c04]], [[3rsm]], [[4il8]] - PaPMM/PGM (mutant) <br />
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**[[2h4l]] - PaPMM/PGM + ribose-1-phosphate<br />
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**[[2h5a]] - PaPMM/PGM + xylose-1-phosphate<br />
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**[[2f7l]] - PMM/PGM – ''Sulfolobus tokodaii''<br />
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**[[3uw2]] – PMM/PGM PGM domain + phosphate – ''Burkholderia thailandensis''<br />
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**[[6mnv]] – XcPMM/PGM + Mg + CH2FG1P – ''Xanthomonas citri''<br />
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**[[6n1e]] – XcPMM/PGM + Mg + methyl-glucose-6-phosphate <br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human phosphomannomutase 1 complex with α-D-mannose-1-phosphate and Mg+2 ion (green) (PDB entry 2fue)

Drag the structure with the mouse to rotate

3D Structures of phosphomannomutase

Updated on 28-August-2023

References

  1. ↑ Matthijs G, Schollen E, Pardon E, Veiga-Da-Cunha M, Jaeken J, Cassiman JJ, Van Schaftingen E. Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13, in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome). Nat Genet. 1997 May;16(1):88-92. PMID:9140401 doi:10.1038/ng0597-88
  2. ↑ Silvaggi NR, Zhang C, Lu Z, Dai J, Dunaway-Mariano D, Allen KN. The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. J Biol Chem. 2006 May 26;281(21):14918-26. Epub 2006 Mar 15. PMID:16540464 doi:http://dx.doi.org/10.1074/jbc.M601505200

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