1q01
From Proteopedia
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| - | [[Image:1q01.gif|left|200px]]<br /><applet load="1q01" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1q01" /> | ||
| - | '''Lebetin peptides, a new class of potent aggregation inhibitors'''<br /> | ||
| - | == | + | ==Lebetin peptides, a new class of potent aggregation inhibitors== |
| - | + | <StructureSection load='1q01' size='340' side='right'caption='[[1q01]]' scene=''> | |
| - | [[ | + | == Structural highlights == |
| - | [[Category: | + | <table><tr><td colspan='2'>[[1q01]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macrovipera_lebetinus Macrovipera lebetinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q01 FirstGlance]. <br> |
| - | [[Category: | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 24 models</td></tr> |
| - | [[Category: Darbon | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q01 OCA], [https://pdbe.org/1q01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q01 RCSB], [https://www.ebi.ac.uk/pdbsum/1q01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q01 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Giralt | + | == Function == |
| - | [[Category: Mabrouk | + | [https://www.uniprot.org/uniprot/LEB_MACLB LEB_MACLB] Lebetins inhibit platelet aggregation induced by thrombin, collagen and PAF-acether. Human platelet aggregation induced by thrombin is inhibited by synthetic lebetin-1-alpha, lebetin-1-beta, lebetin-1-gamma, lebetin-2-alpha and lebetin-2-beta with IC(50) values of 140, 32, 5, 2.5 and 2.8 nM, respectively. Lebetins also inhibit fibrinogen-induced aggregation of alpha-chymotrypsin-treated platelets as well as in vivo collagen-induced thrombocytopenia in rats. Lebetins are not toxic upon intravenous injection into mice and rats.<ref>PMID:11910186</ref> <ref>PMID:8769304</ref> <ref>PMID:9839678</ref> |
| - | [[Category: Marrakchi | + | == References == |
| - | [[Category: Mosbah | + | <references/> |
| - | + | __TOC__ | |
| - | [[Category: Rochat | + | </StructureSection> |
| - | [[Category: Sabatier | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Macrovipera lebetinus]] |
| - | + | [[Category: Darbon H]] | |
| - | + | [[Category: El Ayeb M]] | |
| + | [[Category: Ganzalez MJ]] | ||
| + | [[Category: Giralt E]] | ||
| + | [[Category: Mabrouk K]] | ||
| + | [[Category: Marrakchi N]] | ||
| + | [[Category: Mosbah A]] | ||
| + | [[Category: Rochat H]] | ||
| + | [[Category: Sabatier JM]] | ||
| + | [[Category: Van Rietschoten J]] | ||
Current revision
Lebetin peptides, a new class of potent aggregation inhibitors
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