4hp1

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'''Unreleased structure'''
 
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The entry 4hp1 is ON HOLD until Paper Publication
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==Crystal structure of Tet3 in complex with a non-CpG dsDNA==
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<StructureSection load='4hp1' size='340' side='right'caption='[[4hp1]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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Authors: Chao, X., Tempel, W., Bian, C., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hp1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HP1 FirstGlance]. <br>
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Description: mCpG DNA complex 2
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hp1 OCA], [https://pdbe.org/4hp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hp1 RCSB], [https://www.ebi.ac.uk/pdbsum/4hp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hp1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TET3_XENTR TET3_XENTR] Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. Conversion of 5mC into 5hmC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes, including pax6, rax, sox9 and six3. May also contribute to the regulation of target genes in ways that do not require its enzyme activity.<ref>PMID:23217707</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Xenopus tropicalis]]
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[[Category: Arrowsmith CH]]
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[[Category: Bian C]]
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[[Category: Bountra C]]
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[[Category: Chao X]]
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[[Category: Edwards AM]]
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[[Category: Min J]]
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[[Category: Tempel W]]

Current revision

Crystal structure of Tet3 in complex with a non-CpG dsDNA

PDB ID 4hp1

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