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4hw3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design== | |
| + | <StructureSection load='4hw3' size='340' side='right'caption='[[4hw3]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4hw3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HW3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=19G:3-[3-(4-CHLORO-3,5-DIMETHYLPHENOXY)PROPYL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>19G</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hw3 OCA], [https://pdbe.org/4hw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hw3 RCSB], [https://www.ebi.ac.uk/pdbsum/4hw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hw3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Zhao B]] | ||
Current revision
Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design
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