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3uwk
From Proteopedia
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| - | [[Image:3uwk.png|left|200px]] | ||
| - | + | ==Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation== | |
| + | <StructureSection load='3uwk' size='340' side='right'caption='[[3uwk]], [[Resolution|resolution]] 1.91Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3uwk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UWK FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DF:1-METHYL-6-PHENYL-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE'>0DF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwk OCA], [https://pdbe.org/3uwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uwk RCSB], [https://www.ebi.ac.uk/pdbsum/3uwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uwk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KTHY_PSEAE KTHY_PSEAE] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity). | ||
| - | == | + | ==See Also== |
| - | + | *[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[ | + | [[Category: Large Structures]] |
| - | + | [[Category: Pseudomonas aeruginosa PAO1]] | |
| - | + | [[Category: Chang J]] | |
| - | + | [[Category: Choi JY]] | |
| - | [[Category: | + | [[Category: Desbonnet CR]] |
| - | [[Category: | + | [[Category: Dillman K]] |
| - | [[Category: Chang | + | [[Category: Miller AA]] |
| - | [[Category: Choi | + | [[Category: Miller JR]] |
| - | [[Category: Desbonnet | + | [[Category: Plummer MS]] |
| - | [[Category: Dillman | + | [[Category: Roush WR]] |
| - | [[Category: Miller | + | [[Category: Soutter HH]] |
| - | [[Category: Miller | + | [[Category: Starr J]] |
| - | [[Category: Plummer | + | |
| - | [[Category: Roush | + | |
| - | [[Category: Soutter | + | |
| - | [[Category: Starr | + | |
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Current revision
Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation
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