4esr
From Proteopedia
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| - | [[Image:4esr.png|left|200px]] | ||
| - | + | ==Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL+ Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors== | |
| - | + | <StructureSection load='4esr' size='340' side='right'caption='[[4esr]], [[Resolution|resolution]] 1.53Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4esr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ESR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53Å</td></tr> | |
| - | == | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| - | [[4esr]] is a 2 chain structure with sequence from [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4esr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esr OCA], [https://pdbe.org/4esr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4esr RCSB], [https://www.ebi.ac.uk/pdbsum/4esr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4esr ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | == | + | == Disease == |
| - | < | + | [https://www.uniprot.org/uniprot/AHI1_HUMAN AHI1_HUMAN] Joubert syndrome;Joubert syndrome with ocular defect. The disease is caused by mutations affecting the gene represented in this entry. |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AHI1_HUMAN AHI1_HUMAN] Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Jiang X]] |
| - | [[Category: | + | [[Category: Liu PX]] |
| - | [[Category: | + | [[Category: Lobo P]] |
| - | [[Category: | + | [[Category: Van Petegem XF]] |
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Current revision
Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL+ Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors
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