1f8v

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[[Image:1f8v.png|left|200px]]
 
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{{STRUCTURE_1f8v| PDB=1f8v | SCENE= }}
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==THE STRUCTURE OF PARIACOTO VIRUS REVEALS A DODECAHEDRAL CAGE OF DUPLEX RNA==
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<StructureSection load='1f8v' size='340' side='right'caption='[[1f8v]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1f8v]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Pariacoto_virus Pariacoto virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F8V FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f8v OCA], [https://pdbe.org/1f8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f8v RCSB], [https://www.ebi.ac.uk/pdbsum/1f8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f8v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSD_PAV CAPSD_PAV] Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma (By similarity). Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/1f8v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f8v ConSurf].
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<div style="clear:both"></div>
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===THE STRUCTURE OF PARIACOTO VIRUS REVEALS A DODECAHEDRAL CAGE OF DUPLEX RNA===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[1f8v]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Pariacato_virus Pariacato virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8V OCA].
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[[Category: Large Structures]]
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[[Category: Pariacoto virus]]
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==Reference==
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[[Category: Ball LA]]
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<ref group="xtra">PMID:011135676</ref><references group="xtra"/>
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[[Category: Johnson JE]]
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[[Category: Pariacato virus]]
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[[Category: Johnson KN]]
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[[Category: Ball, L A.]]
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[[Category: Lin T]]
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[[Category: Johnson, J E.]]
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[[Category: Tang L]]
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[[Category: Johnson, K N.]]
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[[Category: Yeager M]]
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[[Category: Lin, T.]]
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[[Category: Tang, L.]]
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[[Category: Yeager, M.]]
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[[Category: Beta-sandwich]]
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[[Category: Coat protein]]
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[[Category: Gamma polypeptide]]
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[[Category: Icosahedral virus]]
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[[Category: Nodavirus]]
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[[Category: Nucleoprotein]]
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[[Category: Protein-rna interaction]]
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[[Category: Rna cage]]
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[[Category: Rna duplex]]
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[[Category: Virus-rna complex]]
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Current revision

THE STRUCTURE OF PARIACOTO VIRUS REVEALS A DODECAHEDRAL CAGE OF DUPLEX RNA

PDB ID 1f8v

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