1ey1

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[[Image:1ey1.png|left|200px]]
 
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{{STRUCTURE_1ey1| PDB=1ey1 | SCENE= }}
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==SOLUTION STRUCTURE OF ESCHERICHIA COLI NUSB==
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<StructureSection load='1ey1' size='340' side='right'caption='[[1ey1]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ey1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EY1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ey1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ey1 OCA], [https://pdbe.org/1ey1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ey1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ey1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ey1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NUSB_ECOLI NUSB_ECOLI] One of the proteins essential for the formation of the RNA polymerase antitermination complex in the presence of lambda phage N protein. However, it is involved in the transcription termination process at certain sites during normal bacterial growth. Binds to the BoxA RNA motif.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/1ey1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ey1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the solution structure of NusB, a transcription antitermination protein from Escherichia coli. The structure reveals a novel, all alpha-helical protein fold. NusB mutations that cause a loss of function (NusB5) or alter specificity for RNA targets (NusB101) are localized to surface residues and likely affect RNA-protein or protein-protein interactions. Residues that are highly conserved among homologs stabilize the protein core. The solution structure of E. coli NusB presented here resembles that of Mycobacterium tuberculosis NusB determined by X-ray diffraction, but differs substantially from a solution structure of E. coli NusB reported earlier.
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===SOLUTION STRUCTURE OF ESCHERICHIA COLI NUSB===
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The structure of the transcriptional antiterminator NusB from Escherichia coli.,Altieri AS, Mazzulla MJ, Horita DA, Coats RH, Wingfield PT, Das A, Court DL, Byrd RA Nat Struct Biol. 2000 Jun;7(6):470-4. PMID:10881193<ref>PMID:10881193</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[1ey1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EY1 OCA].
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<div class="pdbe-citations 1ey1" style="background-color:#fffaf0;"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010881193</ref><ref group="xtra">PMID:014636602</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Altieri, A S.]]
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[[Category: Large Structures]]
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[[Category: Coats, R H.]]
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[[Category: Altieri AS]]
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[[Category: Horita, D A.]]
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[[Category: Byrd RA]]
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[[Category: Mazzulla, M J.]]
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[[Category: Coats RH]]
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[[Category: Wingfield, P T.]]
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[[Category: Horita DA]]
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[[Category: Transcirption termination]]
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[[Category: Mazzulla MJ]]
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[[Category: Transcription]]
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[[Category: Wingfield PT]]

Current revision

SOLUTION STRUCTURE OF ESCHERICHIA COLI NUSB

PDB ID 1ey1

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