1f0c
From Proteopedia
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| - | [[Image:1f0c.png|left|200px]] | ||
| - | + | ==STRUCTURE OF THE VIRAL SERPIN CRMA== | |
| + | <StructureSection load='1f0c' size='340' side='right'caption='[[1f0c]], [[Resolution|resolution]] 2.26Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1f0c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cowpox_virus Cowpox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F0C FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0c OCA], [https://pdbe.org/1f0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f0c RCSB], [https://www.ebi.ac.uk/pdbsum/1f0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f0c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SPI2_CWPXB SPI2_CWPXB] Specific and potent inhibitor of the interleukin-1-beta converting enzyme (ICE) thereby suppressing an interleukin-1 beta response to infection. The inhibition of ICE by crmA is an example of a "cross-class" interaction, in which a serpin inhibits a non-serine proteinase. Also inhibits granzyme B.<ref>PMID:1339309</ref> <ref>PMID:8034697</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/1f0c_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f0c ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Serpin 3D structures|Serpin 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | [[ | + | __TOC__ |
| - | + | </StructureSection> | |
| - | == | + | |
| - | < | + | |
[[Category: Cowpox virus]] | [[Category: Cowpox virus]] | ||
| - | [[Category: Bankston | + | [[Category: Large Structures]] |
| - | [[Category: Liddington | + | [[Category: Bankston LA]] |
| - | [[Category: Renatus | + | [[Category: Liddington RC]] |
| - | [[Category: Salvesen | + | [[Category: Renatus M]] |
| - | [[Category: Snipas | + | [[Category: Salvesen GS]] |
| - | [[Category: Stennicke | + | [[Category: Snipas SJ]] |
| - | [[Category: Turk | + | [[Category: Stennicke HR]] |
| - | [[Category: Zhou | + | [[Category: Turk D]] |
| - | + | [[Category: Zhou Q]] | |
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Current revision
STRUCTURE OF THE VIRAL SERPIN CRMA
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Categories: Cowpox virus | Large Structures | Bankston LA | Liddington RC | Renatus M | Salvesen GS | Snipas SJ | Stennicke HR | Turk D | Zhou Q
