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1f0c

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[[Image:1f0c.png|left|200px]]
 
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{{STRUCTURE_1f0c| PDB=1f0c | SCENE= }}
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==STRUCTURE OF THE VIRAL SERPIN CRMA==
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<StructureSection load='1f0c' size='340' side='right'caption='[[1f0c]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1f0c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cowpox_virus Cowpox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F0C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0c OCA], [https://pdbe.org/1f0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f0c RCSB], [https://www.ebi.ac.uk/pdbsum/1f0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f0c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPI2_CWPXB SPI2_CWPXB] Specific and potent inhibitor of the interleukin-1-beta converting enzyme (ICE) thereby suppressing an interleukin-1 beta response to infection. The inhibition of ICE by crmA is an example of a "cross-class" interaction, in which a serpin inhibits a non-serine proteinase. Also inhibits granzyme B.<ref>PMID:1339309</ref> <ref>PMID:8034697</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/1f0c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f0c ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF THE VIRAL SERPIN CRMA===
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==See Also==
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*[[Serpin 3D structures|Serpin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[1f0c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cowpox_virus Cowpox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0C OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:010903953</ref><references group="xtra"/>
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[[Category: Cowpox virus]]
[[Category: Cowpox virus]]
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[[Category: Bankston, L A.]]
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[[Category: Large Structures]]
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[[Category: Liddington, R C.]]
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[[Category: Bankston LA]]
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[[Category: Renatus, M.]]
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[[Category: Liddington RC]]
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[[Category: Salvesen, G S.]]
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[[Category: Renatus M]]
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[[Category: Snipas, S J.]]
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[[Category: Salvesen GS]]
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[[Category: Stennicke, H R.]]
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[[Category: Snipas SJ]]
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[[Category: Turk, D.]]
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[[Category: Stennicke HR]]
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[[Category: Zhou, Q.]]
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[[Category: Turk D]]
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[[Category: Apoptosis]]
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[[Category: Zhou Q]]
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[[Category: Caspase inhibitor]]
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[[Category: Protease inhibitor]]
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[[Category: Serpin]]
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[[Category: Viral protein]]
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Current revision

STRUCTURE OF THE VIRAL SERPIN CRMA

PDB ID 1f0c

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