1f9s
From Proteopedia
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| - | [[Image:1f9s.png|left|200px]] | ||
| - | + | ==CRYSTAL STRUCTURE OF PLATELET FACTOR 4 MUTANT 2== | |
| + | <StructureSection load='1f9s' size='340' side='right'caption='[[1f9s]], [[Resolution|resolution]] 2.38Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1f9s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F9S FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f9s OCA], [https://pdbe.org/1f9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f9s RCSB], [https://www.ebi.ac.uk/pdbsum/1f9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f9s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PLF4_HUMAN PLF4_HUMAN] Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.<ref>PMID:7644496</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/1f9s_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f9s ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[C-X-C motif chemokine 3D structures|C-X-C motif chemokine 3D structures]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Aster | + | [[Category: Large Structures]] |
| - | [[Category: Doyle | + | [[Category: Aster R]] |
| - | [[Category: Edwards | + | [[Category: Doyle M]] |
| - | [[Category: Faulk | + | [[Category: Edwards B]] |
| - | [[Category: Visentin | + | [[Category: Faulk T]] |
| - | [[Category: Yang | + | [[Category: Visentin G]] |
| - | + | [[Category: Yang J]] | |
| - | + | ||
Current revision
CRYSTAL STRUCTURE OF PLATELET FACTOR 4 MUTANT 2
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Categories: Homo sapiens | Large Structures | Aster R | Doyle M | Edwards B | Faulk T | Visentin G | Yang J
