Ribosomal protein S6 kinase

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[[Image:2z7q.png|left|200px|thumb|Crystal Structure of Ribosomal protein S6 kinase [[2z7q]]]]
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<StructureSection load='' size='350' side='right' caption='Human ribosomal protein S6 kinase α−1 complex with the inhibitor purvalanol (PDB entry [[2z7s]])' scene='43/434545/Cv/2'>
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{{STRUCTURE_2z7q| PDB=2z7q | SIZE=300| SCENE=Ribosomal_protein_S6_kinase/Cv/1 |right|CAPTION=Ribosomal protein S6 kinase complex with AMP-PCP and Mg+2 ion (green) [[2z7q]] }}
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__TOC__
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== Function ==
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[[Ribosomal protein S6 kinase]] (RPS6K) regulates RPS6<ref>PMID:22168436</ref>. RPS6K activity controls the ribosome biogenesis transcriptional program.
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*'''Ribosomal protein S6 kinase alpha''' confers resistance towards therapy of acute myeloid leukaemia using venetoclax/azacitidine<ref>PMID:37414921</ref>.
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== Relevance ==
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hRPS6K α is overexpressed in breast cancer and is associated with poor prognosis<ref>PMID:19085255</ref>. Inhibitors of RPS6S are studied as potential therapeutic agents for treatment of variety of diseases including diabetes and cancer<ref>PMID:24072592</ref>.
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[[Ribosomal protein S6 kinase]] (RPS6K) regulates RPS6. The images at the left and at the right correspond to one representative RPS6K, ''i.e.'' the crystal structure of human Ribosomal protein S6 kinase ([[2z7q]]).
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== Structural highlights ==
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The <scene name='43/434545/Cv/5'>inhibitor purvalanol binds hRPS6K in the ATP-binding pocket between the N- and C-terminal lobes</scene><ref>PMID:17965187</ref>. <scene name='43/434545/Cv/6'>Active site</scene>. Water molecule are shown as red sphere.
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== 3D Structures of Ribosomal protein S6 kinase ==
== 3D Structures of Ribosomal protein S6 kinase ==
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[[Ribosomal protein S6 kinase 3D structures]]
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[[3kn5]], [[3kn6]], [[2wnt]] – hRPS6K C-terminal residues 414-738 – human<br />
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== References ==
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[[3a60]], [[3a61]], [[3a62]] - hRPS6K residues 75-399<br />
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<references/>
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[[2z7q]] - hRPS6K residues 33-353<br />
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</StructureSection>
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[[1vzo]] - hRPS6K residues 1-350 (mutant)<br />
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[[2z7s]] - hRPS6K residues 33-353+purvalnol A<br />
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[[2z7r]] - hRPS6K residues 33-353+staurosporine<br />
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[[3g51]] - mRPS6K N-terminal – mouse<br />
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[[2qr7]], [[2qr8]] - mRPS6K (mutant)<br />
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human ribosomal protein S6 kinase α−1 complex with the inhibitor purvalanol (PDB entry 2z7s)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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