4g6a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:01, 30 October 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4g6a.png|left|200px]]
 
-
{{STRUCTURE_4g6a| PDB=4g6a | SCENE= }}
+
==Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33==
 +
<StructureSection load='4g6a' size='340' side='right'caption='[[4g6a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_hominis Hepacivirus hominis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G6A FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.501&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6a OCA], [https://pdbe.org/4g6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g6a RCSB], [https://www.ebi.ac.uk/pdbsum/4g6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g6a ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q9YK84_9HEPC Q9YK84_9HEPC]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
We have determined the crystal structure of broadly neutralizing antibody (bnAb) AP33 bound to a peptide corresponding to hepatitis C virus (HCV) E2 envelope glycoprotein antigenic site 412-423. Comparison with bnAb HCV1 bound to the same epitope reveals a different angle of approach to the antigen by bnAb AP33, and slight variation in its beta-hairpin conformation of the epitope. These structures establish two different modes of binding to E2 that antibodies adopt to neutralize diverse HCV.
-
===Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33===
+
Structure of hepatitis C virus envelope glycoprotein E2 antigenic site 412-423 in complex with antibody AP33.,Kong L, Giang E, Nieusma T, Robbins JB, Deller MC, Stanfield RL, Wilson IA, Law M J Virol. 2012 Sep 12. PMID:22973046<ref>PMID:22973046</ref>
-
{{ABSTRACT_PUBMED_22973046}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 4g6a" style="background-color:#fffaf0;"></div>
-
[[4g6a]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA].
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Hepacivirus hominis]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Kong, L.]]
+
[[Category: Large Structures]]
-
[[Category: Law, M.]]
+
[[Category: Kong L]]
-
[[Category: Wilson, I A.]]
+
[[Category: Law M]]
-
[[Category: Immune system]]
+
[[Category: Wilson IA]]
-
[[Category: Immunoglobulin fold]]
+

Current revision

Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33

PDB ID 4g6a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4g6a"
Personal tools