Tryptase inhibitor
From Proteopedia
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| - | <StructureSection load='1ldt' size=' | + | <StructureSection load='1ldt' size='350' side='right' caption='Structure of leech tryptase inhibitor (magenta) complex with trypsin (cyan) and Ca+2 ion (green) (PDB entry [[1ldt]])' scene='51/517374/Cv/1'> |
| - | '''Tryptase inhibitors''' (TI) are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations. | + | '''Tryptase inhibitors''' (TI) are protein inhibitors of tryptase belonging to the group of Kazal-type inhibitors and exhibiting a distinctive disulfide pattern<ref>PMID:9242660</ref>. |
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| + | == Relevance == | ||
| + | TI are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations. | ||
| + | *<scene name='51/517374/Cv/3'>Tryptase inhibitor/trypsin interactions</scene> (PDB entry [[1ldt]]). | ||
| + | </StructureSection> | ||
==3D structures of tryptase inhibitor== | ==3D structures of tryptase inhibitor== | ||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *Leech-derived tryptase inhibitor | |
| - | [[1ldt]] – MlTI + trypsin – Medicinal leech<br /> | + | **[[1ldt]] – MlTI + trypsin – Medicinal leech<br /> |
| - | [[1an1]] - MlTI (mutant) + trypsin<br /> | + | **[[1an1]] - MlTI (mutant) + trypsin<br /> |
| - | [[2kmo]], [[2kmp]], [[2kmq]], [[2kmr]] – MlTI - NMR | + | **[[2kmo]], [[2kmp]], [[2kmq]], [[2kmr]] – MlTI - NMR |
| - | + | *Tick-derived tryptase inhibitor | |
| - | [[2uux]] – tTI residues 44-96 – tick<br /> | + | **[[2uux]] – tTI residues 44-96 – tick<br /> |
| - | [[2uuy]] - tTI + trypsin<br /> | + | **[[2uuy]] - tTI + trypsin<br /> |
| - | [[2lfk]], [[2lfl]] – tTI - NMR | + | **[[2lfk]], [[2lfl]] – tTI - NMR |
| - | + | }} | |
| - | </ | + | == References == |
| + | <references/> | ||
| + | [[Category: Topic Page]] | ||
Current revision
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3D structures of tryptase inhibitor
Updated on 03-October-2019
References
- ↑ Stubbs MT, Morenweiser R, Sturzebecher J, Bauer M, Bode W, Huber R, Piechottka GP, Matschiner G, Sommerhoff CP, Fritz H, Auerswald EA. The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition. J Biol Chem. 1997 Aug 8;272(32):19931-7. PMID:9242660
