3w0f

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'''Unreleased structure'''
 
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The entry 3w0f is ON HOLD
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==Crystal structure of mouse Endonuclease VIII-LIKE 3 (mNEIL3)==
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<StructureSection load='3w0f' size='340' side='right'caption='[[3w0f]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Liu, M., Imamura, K., Averill, A., Wallace, S., Doublie, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3w0f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W0F FirstGlance]. <br>
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Description: Crystal structure of mouse Endonuclease VIII-LIKE 3 (mNEIL3)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0f OCA], [https://pdbe.org/3w0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w0f RCSB], [https://www.ebi.ac.uk/pdbsum/3w0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w0f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEIL3_MOUSE NEIL3_MOUSE] DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.<ref>PMID:20185759</ref> <ref>PMID:22065741</ref> <ref>PMID:22569481</ref> <ref>PMID:22959434</ref> <ref>PMID:23305905</ref> <ref>PMID:23313161</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Averill AM]]
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[[Category: Doublie S]]
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[[Category: Imamura K]]
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[[Category: Liu M]]
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[[Category: Wallace SS]]

Current revision

Crystal structure of mouse Endonuclease VIII-LIKE 3 (mNEIL3)

PDB ID 3w0f

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