2lx1
From Proteopedia
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| - | [[Image:2lx1.jpg|left|200px]] | ||
| - | + | ==Major Conformation of the Internal Loop 5'GAGU/3'UGAG== | |
| + | <StructureSection load='2lx1' size='340' side='right'caption='[[2lx1]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2lx1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LX1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lx1 OCA], [https://pdbe.org/2lx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lx1 RCSB], [https://www.ebi.ac.uk/pdbsum/2lx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lx1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The RNA duplex, (5'GACGAGUGUCA)(2), has two conformations in equilibrium. The nuclear magnetic resonance solution structure reveals that the major conformation of the loop, 5'GAGU/3'UGAG, is novel and contains two unusual Watson-Crick/Hoogsteen GG pairs with G residues in the syn conformation, two A residues stacked on each other in the center of the helix with inverted sugars, and two bulged-out U residues. The structure provides a benchmark for testing approaches for predicting local RNA structure and a sequence that allows the design of a unique arrangement of functional groups and/or a conformational switch into nucleic acids. | ||
| - | + | Novel conformation of an RNA structural switch.,Kennedy SD, Kierzek R, Turner DH Biochemistry. 2012 Nov 20;51(46):9257-9. doi: 10.1021/bi301372t. Epub 2012 Nov, 12. PMID:23134175<ref>PMID:23134175</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2lx1" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Kennedy SD]] |
| - | [[Category: | + | [[Category: Turner DH]] |
| - | + | ||
Current revision
Major Conformation of the Internal Loop 5'GAGU/3'UGAG
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