1nf5

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[[Image:1nf5.png|left|200px]]
 
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{{STRUCTURE_1nf5| PDB=1nf5 | SCENE= }}
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==Crystal Structure of Lactose Synthase, Complex with Glucose==
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<StructureSection load='1nf5' size='340' side='right'caption='[[1nf5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal Structure of Lactose Synthase, Complex with Glucose===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nf5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1j8w 1j8w]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NF5 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11419947}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nf5 OCA], [https://pdbe.org/1nf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nf5 RCSB], [https://www.ebi.ac.uk/pdbsum/1nf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nf5 ProSAT]</span></td></tr>
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[[1nf5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1j8w 1j8w]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NF5 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LALBA_MOUSE LALBA_MOUSE] Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nf/1nf5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nf5 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Galactosyltransferase|Galactosyltransferase]]
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*[[Alpha-lactalbumin 3D structures|Alpha-lactalbumin 3D structures]]
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*[[Lactalbumin|Lactalbumin]]
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*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011419947</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Qasba, P K.]]
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[[Category: Qasba PK]]
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[[Category: Ramakrishnan, B.]]
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[[Category: Ramakrishnan B]]
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[[Category: Conformational change]]
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[[Category: Glucose binding]]
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[[Category: Lactose synhtase]]
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[[Category: Transferase modulator]]
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[[Category: Transferase-transferase complex]]
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Current revision

Crystal Structure of Lactose Synthase, Complex with Glucose

PDB ID 1nf5

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