4gle
From Proteopedia
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| - | [[Image:4gle.jpg|left|200px]] | ||
| - | + | ==SacUVDE in complex with 6-4PP-containing DNA== | |
| + | <StructureSection load='4gle' size='340' side='right'caption='[[4gle]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gle]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GLE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5PY:1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-5-METHYLPYRIMIDIN-2(1H)-ONE'>5PY</scene>, <scene name='pdbligand=64T:5-HYDROXY-THYMIDINE-5-MONOPHOSPHATE'>64T</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gle OCA], [https://pdbe.org/4gle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gle RCSB], [https://www.ebi.ac.uk/pdbsum/4gle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gle ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q4J9T1_SULAC Q4J9T1_SULAC] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Repairing damaged DNA is essential for an organism's survival. UV damage endonuclease (UVDE) is a DNA-repair enzyme that can recognize and incise different types of damaged DNA. We present the structure of Sulfolobus acidocaldarius UVDE on its own and in a pre-catalytic complex with UV-damaged DNA containing a 6-4 photoproduct showing a novel 'dual dinucleotide flip' mechanism for recognition of damaged dipyrimidines: the two purines opposite to the damaged pyrimidine bases are flipped into a dipurine-specific pocket, while the damaged bases are also flipped into another cleft. | ||
| - | + | UV damage endonuclease employs a novel dual-dinucleotide flipping mechanism to recognize different DNA lesions.,Meulenbroek EM, Peron Cane C, Jala I, Iwai S, Moolenaar GF, Goosen N, Pannu NS Nucleic Acids Res. 2012 Dec 11. PMID:23221644<ref>PMID:23221644</ref> | |
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4gle" style="background-color:#fffaf0;"></div> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Endonuclease 3D structures|Endonuclease 3D structures]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Sulfolobus acidocaldarius]] | [[Category: Sulfolobus acidocaldarius]] | ||
| - | + | [[Category: Goosen N]] | |
| - | [[Category: Goosen | + | [[Category: Iwai S]] |
| - | [[Category: Iwai | + | [[Category: Jala I]] |
| - | [[Category: Jala | + | [[Category: Meulenbroek EM]] |
| - | [[Category: Meulenbroek | + | [[Category: Moolenaar GF]] |
| - | [[Category: Moolenaar | + | [[Category: Pannu NS]] |
| - | [[Category: Pannu | + | [[Category: Peron Cane C]] |
| - | [[Category: | + | |
| - | + | ||
Current revision
SacUVDE in complex with 6-4PP-containing DNA
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