1frw

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[[Image:1frw.png|left|200px]]
 
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{{STRUCTURE_1frw| PDB=1frw | SCENE= }}
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==STRUCTURE OF E. COLI MOBA WITH BOUND GTP AND MANGANESE==
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<StructureSection load='1frw' size='340' side='right'caption='[[1frw]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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===STRUCTURE OF E. COLI MOBA WITH BOUND GTP AND MANGANESE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1frw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FRW FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10978347}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1frw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1frw OCA], [https://pdbe.org/1frw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1frw RCSB], [https://www.ebi.ac.uk/pdbsum/1frw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1frw ProSAT]</span></td></tr>
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[[1frw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FRW OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/MOBA_ECOLI MOBA_ECOLI] Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. Is also involved in the biosynthesis of the bis-MGD form of the Moco cofactor (Mo-bisMGD) in which the metal is symmetrically ligated by the dithiolene groups of two MGD molecules. Is necessary and sufficient for the in vitro activation of the DMSOR molybdoenzyme that uses the Mo-bisMGD form of molybdenum cofactor, which implies formation and efficient insertion of the cofactor into the enzyme without the need of a chaperone. Is specific for GTP since other nucleotides such as ATP and GMP can not be utilized.<ref>PMID:8020507</ref> <ref>PMID:1648082</ref> <ref>PMID:10978348</ref> <ref>PMID:21081498</ref>
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<ref group="xtra">PMID:010978347</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/1frw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1frw ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Lake, M W.]]
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[[Category: Large Structures]]
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[[Category: Rajagopalan, K V.]]
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[[Category: Lake MW]]
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[[Category: Schindelin, H.]]
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[[Category: Rajagopalan KV]]
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[[Category: Temple, C A.]]
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[[Category: Schindelin H]]
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[[Category: Metal binding protein]]
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[[Category: Temple CA]]
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[[Category: Moco biosynthesis]]
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Current revision

STRUCTURE OF E. COLI MOBA WITH BOUND GTP AND MANGANESE

PDB ID 1frw

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