1g27

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[[Image:1g27.png|left|200px]]
 
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{{STRUCTURE_1g27| PDB=1g27 | SCENE= }}
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==CRYSTAL STRUCTURE OF E.COLI POLYPEPTIDE DEFORMYLASE COMPLEXED WITH THE INHIBITOR BB-3497==
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<StructureSection load='1g27' size='340' side='right'caption='[[1g27]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF E.COLI POLYPEPTIDE DEFORMYLASE COMPLEXED WITH THE INHIBITOR BB-3497===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1g27]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G27 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11158755}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB1:2-[(FORMYL-HYDROXY-AMINO)-METHYL]-HEXANOIC+ACID+(1-DIMETHYLCARBAMOYL-2,2-DIMETHYL-PROPYL)-AMIDE'>BB1</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g27 OCA], [https://pdbe.org/1g27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g27 RCSB], [https://www.ebi.ac.uk/pdbsum/1g27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g27 ProSAT]</span></td></tr>
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[[1g27]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G27 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/DEF_ECOLI DEF_ECOLI] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
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<ref group="xtra">PMID:011158755</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/1g27_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g27 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Formylmethionine deformylase]]
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[[Category: Large Structures]]
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[[Category: Baker, P J.]]
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[[Category: Baker PJ]]
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[[Category: Barynin, V.]]
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[[Category: Barynin V]]
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[[Category: Beckett, P.]]
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[[Category: Beckett P]]
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[[Category: Brown, A.]]
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[[Category: Brown A]]
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[[Category: Catlin, C.]]
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[[Category: Catlin C]]
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[[Category: Clements, J M.]]
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[[Category: Clements JM]]
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[[Category: Hunter, M G.]]
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[[Category: Hunter MG]]
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[[Category: Lobell, M.]]
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[[Category: Lobell M]]
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[[Category: Palan, S.]]
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[[Category: Palan S]]
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[[Category: Rice, D W.]]
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[[Category: Rice DW]]
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[[Category: Rodgers, H F.]]
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[[Category: Rodgers HF]]
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[[Category: Thomas, W.]]
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[[Category: Thomas W]]
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[[Category: Whittaker, M.]]
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[[Category: Whittaker M]]
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[[Category: Bb-3497]]
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[[Category: Hydrolase]]
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[[Category: Inhibition]]
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[[Category: Polypeptide deformylase]]
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Current revision

CRYSTAL STRUCTURE OF E.COLI POLYPEPTIDE DEFORMYLASE COMPLEXED WITH THE INHIBITOR BB-3497

PDB ID 1g27

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